Yunis Varon Syndrome
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NORD is very grateful to Lina Basel-Vanagaite, MD ,PhD, Director, Clinical Genetics Service, Schneider Children's Medical Center of Israel, for assistance in the preparation of this report.
Synonyms of Yunis Varon Syndrome
- absent/hypoplastic fingers
- clavicular hypoplasia
- sparse hair
- No subdivisions found.
Yunis-Varon syndrome is an extremely rare genetic multisystem disorder with defects affecting the skeletal system, ectodermal tissue (hair and teeth); and cardiorespiratory (i.e., heart and lungs) systems. It is characterized by large fontanelles, clavicular hypoplasia, characteristic facial features and/or abnormalities of fingers and toes. Characteristic features may include microcephaly, ear abnormalities, anteverted nares, midfacial hypoplasia, tented upper lip and small jaw (micrognathia), sparse or absent eyebrows and/or eyelashes. Abnormalities of the fingers and toes may include absence (aplasia) or underdevelopment (hypoplasia) of the fingers and toes. In most cases, infants with this disorder experience severe feeding problems and respiratory difficulties. In addition, affected infants may have heart defects (e.g., abnormal enlargement of the heart muscle [hypertrophic cardiomyopathy]). Frequently, feeding problems, respiratory difficulties, and/or heart defects may result in life-threatening complications during infancy. Yunis-Varon syndrome is inherited as an autosomal recessive trait.
Organizations related to Yunis Varon Syndrome
(Please note that some of these organizations may provide information concerning certain conditions potentially associated with this disorder [e.g., respiratory and heart problems, skeletal dysplasia, craniofacial deformities, etc.].)
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