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Catel Manzke Syndrome
Abstract
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Synonyms of Catel Manzke Syndrome
- Catel-Manzke Type Palatodigital Syndrome
- Hyperphalangy-Clinodactyly of Index Finger with Pierre Robin Syndrome
- Index Finger Anomaly with Pierre Robin Syndrome
- Pierre Robin Syndrome with Hyperphalangy and Clinodactyly
Disorder Subdivisions
- No subdivisions found.
General Discussion
Catel-Manzke syndrome is a rare genetic disorder characterized by distinctive abnormalities of the index fingers; the classic features of Pierre Robin syndrome; and, in some cases, additional physical findings. Pierre Robin syndrome refers to a sequence of abnormalities that may occur as a distinct syndrome or as part of another underlying disorder. Pierre Robin syndrome is characterized by an unusually small jaw (micrognathia), downward displacement or retraction of the tongue (glossoptosis), and incomplete closure of the roof of the mouth (cleft palate).
Infants with Catel-Manzke syndrome have an extra (supernumerary), irregularly shaped bone (i.e., hyperphalangy) located between the first bone of the index finger (proximal phalanx) and the corresponding bone within the body of the hand (second metacarpal). As a result, the index fingers may be fixed in an abnormally bent position (clinodactyly). In some cases, additional abnormalities of the hands may also be present. Due to the presence of micrognathia, glossoptosis, and cleft palate, affected infants may have feeding and breathing difficulties; growth deficiency; repeated middle ear infections (otitis media); and/or other complications. In addition, some infants with the syndrome may have structural abnormalities of the heart that are present at birth (congenital heart defects). The range and severity of symptoms and findings may vary from case to case. Catel-Manzke syndrome usually appears to occur randomly, for unknown reasons (sporadically).
Organizations related to Catel Manzke Syndrome
(Please note that some of these organizations may provide information concerning certain conditions potentially associated with this disorder [e.g., Pierre Robin syndrome, congenital heart defects, etc.].)
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