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Congenital Fibrosis of the Extraocular Muscles

NORD is very grateful to Elizabeth C. Engle, MD, Professor of Neurology and Ophthalmology, Harvard Medical School and Children's Hospital Boston; Investigator, Howard Hughes Medical Institute, for assistance in the preparation of this report.

Synonyms of Congenital Fibrosis of the Extraocular Muscles

  • congenital fibrosis syndrome

Disorder Subdivisions

  • congenital fibrosis of the extraocular muscles 1 (CFEOM 1)
  • congenital fibrosis of the extraocular muscles 2 (CFEOM 2)
  • congenital fibrosis of the extraocular muscles 3 (CFEOM 3)
  • Tukel syndrome

General Discussion

Congenital fibrosis of the extraocular muscles (CFEOM) includes at least five rare genetic eye movement disorders present at birth that are characterized by incomitant strabismus. Specifically, there is an inability to move the eyes in certain directions (opthalmoplegia), droopy eyelids (ptosis) and eyes that are fixed in an abnormal position. The oculomotor nucleus and nerve (cranial nerve III) and the muscles it serves and, in some cases the trochlear nucleus and nerve (cranial nerve IV) and/or the abducens nucleus and nerve (cranial nerve VI) and the muscles they serve are affected.

Symptoms

Affected individuals have limited ability to move their eyes vertically (upward and downward) and can have variable limitations in moving their eyes horizontally. CFEOM is also frequently associated with droopy eyelids (ptosis) and eyes that are fixed in an abnormal position. Individuals with CFEOM often have their eyes fixed in a downward position, and elevate the chin so they can see. These disorders have been classified as CFEOM1, CFEOM2, and CFEOM3 based on ophthalmologic findings and molecular genetic testing. CFEOM3 can be characterized by additional involvement of the peripheral and central nervous system in addition to the eye findings. Tukel syndrome is characterized by missing and webbed fingers and toes in addition to the eye findings. These disorders do not worsen over time.

Causes

CFEOM 1 and CFEOM 3 are inherited as autosomal dominant genetic conditions. CFEOM 2 and Tukel syndrome are inherited as autosomal recessive genetic conditions.

Dominant genetic disorders occur when only a single copy of an abnormal gene is necessary to cause a particular disease. The abnormal gene can be inherited from either parent or can be the result of a new mutation (gene change) in the affected individual. The risk of passing the abnormal gene from affected parent to offspring is 50% for each pregnancy. The risk is the same for males and females.

Recessive genetic disorders occur when an individual inherits two copies of an abnormal gene for the same trait, one from each parent. If an individual receives one normal gene and one gene for the disease, the person will be a carrier for the disease but usually will not show symptoms. The risk for two carrier parents to both pass the defective gene and have an affected child is 25% with each pregnancy. The risk to have a child who is a carrier like the parents is 50% with each pregnancy. The chance for a child to receive normal genes from both parents and be genetically normal for that particular trait is 25%. The risk is the same for males and females.

All individuals carry 4-5 abnormal genes. Parents who are close relatives (consanguineous) have a higher chance than unrelated parents to both carry the same abnormal gene, which increases the risk to have children with a recessive genetic disorder.

Several genes have been found to be associated with the CFEOM syndromes:

KIF21A gene - CFEOM 1 and rarely CFEOM 3
PHOX2A gene - CFEOM 2
TUBB3 gene - CFEOM3 and rarely CFEOM1, and can be associated with additional findings, referred to as the TUBB3 syndromes.
TUBB2B gene - CFEOM3 in association with polymicrogyria
FEOM4 locus on chromosome 13 - CFEOM 3
TUKLS locus on chromosome 21 - Tukel syndrome

Affected Populations

CFEOM are rare disorders that have been seen in a range of diverse ethnic populations and affect males and females. A minimum prevalence has been estimated to be 1 in 230,000.

Related Disorders

Strabismus is a common group of eye movement disorders in which the eyes are not properly yoked together and one or both eyes are misaligned and cannot be voluntarily controlled. Strabismus is either concomitant or incomitant. Concomitant strabismus occurs when the misalignment, or the angle of deviation between the two eyes, remains constant and independent of the direction of gaze. Strabismus is incomitant when the misalignment varies with gaze direction. Congenital cranial dysinnervation disorders include the various forms of incomitant strabismus such as CFEOM, Duane syndrome, Moebius syndrome, and Brown syndrome. Strabismus may be an isolated finding or found in association with other birth defects.

Duane syndrome is an eye movement disorder present at birth characterized by horizontal eye movement limitation (adduction), outward eye movement limitation toward the ear (abduction), or in both directions. In addition, when the affected eye moves inward toward the nose, the eyeball retracts (pulls in) and the eye opening (palpebral fissure) narrows. In some cases, when the eye attempts to look inward, it moves upward or downward. (For more information on this disorder, choose "Duane syndrome" as your search term in the Rare Disease Database.)

Moebius syndrome is a congenital disorder in which the eye(s) cannot move fully outward toward the ear (abduction), and there is facial weakness.

Brown syndrome is a rare eye movement disorder in which the affected eye is unable to look inward towards the nose (adduction) and upward, and may be out of alignment with the unaffected eye. Brown syndrome is thought to be caused by abnormalities in the superior oblique tendon sheath in the muscle that surrounds the eyeball. (For more information on this disorder, choose "Brown syndrome" as your search term in the Rare Disease Database.)

Standard Therapies

Diagnosis
The diagnosis of CFEOM is made by a thorough eye examination, with special attention to the presence of other eye or systemic malformations. Measurements of the ocular (eye) misalignment, ocular range of motion, head turn, glove (eyeball) retraction, palpebral fissure (eye opening) size, and upward and downward movement of the eye are taken. Forced duction (the rotation of the eye by its extraocular muscles) and vision tests are also recommended.

Molecular genetic testing is available to identify mutations in the KIF21A, PHOX2A, TUBB3, and TUBB2B genes and confirms the diagnosis.

Treatment
Eyeglasses and contact lenses are used to treat focusing problems (refractive errors). Reduced vision that is not correctable by these devices (amblyopia) can be treated by making the child use the eye with the reduced vision. This can be done by inserting a drop of atropine in the stronger eye once a day to temporarily blur the vision so that the child will prefer to use the eye with amblyopia or by placing a patch over the stronger eye.

The standard management of CFEOM may involve surgery. The goal of surgery is the elimination or improvement of an unacceptable head position, the reduction of ptosis, and the elimination or reduction of significant misalignment of the eyes. Successful surgery at a young age may avoid loss of vision in one or both eyes. However, surgery does not eliminate the fundamental abnormality, and no surgical technique has been completely successful in eliminating the abnormal eye movements. The choice of procedure must be individualized.

Investigational Therapies

Genetic research studies are in progress at the Engle Laboratory at Boston Children's Hospital to identify and characterize the gene(s) involved in CFEOM. With funding from the National Institutes of Health (NIH), Dr. Elizabeth Engle, a pediatric neurologist and genetic researcher, is leading a research team conducting genetic studies to identify genes involved in rare eye movement disorders that are present at birth. The research team is interested in enrolling individuals who would like to participate. Participation requires giving the laboratory access to pertinent medical records and donating a small sample of blood. Contact Caroline Andrews (candrews@enders.tch.harvard.edu or 617- 919-2168) to obtain further information about these studies or if you are interested in enrolling a patient or participating yourself. Information on current clinical trials is posted on the Internet at www.clinicaltrials.gov. All studies receiving U.S. Government funding, and some supported by private industry, are posted on this government web site.

For information about clinical trials being conducted at the NIH Clinical Center in Bethesda, MD, contact the NIH Patient Recruitment Office:

Tollfree: (800) 411-1222
TTY: (866) 411-1010
Email: prpl@cc.nih.gov

For information about clinical trials sponsored by private sources, contact:
www.centerwatch.com

For information about clinical trials conducted in Europe, contact:
https://www.clinicaltrialsregister.eu/

Contact for additional information about congenital fibrosis of the extraocular muscles:

Elizabeth C. Engle, M.D.
Professor of Neurology and Ophthalmology, Harvard Medical School
CL14075, Neurology Research
Children's Hospital Boston
300 Longwood Avenue, Boston, MA 02115
Tel: (617) 919-4030
Fax: (617) 919-2769

Organizations related to Congenital Fibrosis of the Extraocular Muscles

References

TEXTBOOKS
Engle E, The Genetics of Strabismus: Duane, Moebius, and Fibrosis Syndromes. In: Traboulsi E ed., Genetic Diseases of the Eye: A Textbook and Atlas. New York: Oxford University Press; 1998:477-51

REVIEW ARTICLES
Nugent AA, Kolpak LA, Engle EC. Human disorders of axon guidance. Curr Opin Neurobiol. 2012 Mar 5. [Epub ahead of print]. PubMed # 22398400 NIHMSID #363464

Tischfield MA, Cederquist GY, Gupta ML Jr, Engle EC. Phenotypic spectrum of the tubulin-related disorders and functional implications of disease-causing mutations. Curr Opin Genet Dev. 2011 Jun;21(3):286-94. Epub 2011 Feb 1. PMCID: PMC3100401

Engle EC. Human genetic disorders of axon guidance. Cold Spring Harbor Perspect. Biol. 2010 Mar;2(3):a001784. PMCID: PMC2829956

JOURNAL ARTICLES
Cederquist GY, Luchniak A, Tischfield MA, et al. An inherited TUBB2B mutation alters a kinesin binding site and causes polymicrogyria, CFEOM, and axon dysinnervation. Human Molecular Genetics. 2012, Sept 21 (epub ahead of print) in press.

Tischfield, M.A., Baris, H.N., Wu, C., et al. Human TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance. Cell. 2010 Jan 8;140(1):74-87. PMCID: PMC3164117

Yamada K, Chan W-M, Andrews C, et al. Neurological features of congenital fibrosis of the extraocular muscles type 2 with mutations in PHOX2A. Brain. 2006;129(9):2363-74. Epub 2006 Jun 30.

Aubourg P, Krahn M, Bernard R, et al. Assignment of a new congenital fibrosis of extraocular muscles type 3 (CFEOM3) locus, FEOM4, based on a balanced translocation t(2;13) (q37.3;q12.11) and identification of candidate genes. J Med Genet. 2005; 42: 253-9.

Demer JL, Clark RA, Engle EC. Magnetic resonance imaging evidence for widespread orbital dysinnervation in congenital fibrosis of extraocular muscles due to mutations in KIF21A. Investigative Ophthalmology & Visual Science. 2005 Feb;46(2):530-9.

Tukel T, Uzumcu A, Gezer A, et al. A new syndrome, congenital extraocular muscle fibrosis with ulnar hand anomalies, maps to chromosome 21qter. J Med Genet. 2005; 42: 408-15.

Engle EC. KIF21A mutations are a rare cause of congenital fibrosis of the extraocular muscles type 3. Investigative Ophthalmology & Visual Science. 2004;45:2218-2223.

Yamada K, Andrews C, Chan W-M, et al. Heterozygous mutations of the kinesin KIF21A in congenital fibrosis of the extraocular muscles type 1 (CFEOM1). Nature Genetics. 2003;35:318-321.

Nakano M, Yamada K, Fain J, Sener EC, Selleck CJ, Awad AH, Zwaan J, Mullaney PB, Bosley TM, Engle EC. Homozygous mutations in ARIX (PHOX2A) result in congenital fibrosis of the extraocular muscles type 2 (CFEOM2). Nature Genetics. 2001;29:315-320.

Traboulsi EI, Lee BA, Mousawi A et al. Evidence of genetic heterogeneity in autosomal recessive congenital fibrosis of the extraocular muscles. Am J Ophthalmol. 2000;129: 658-62.

Engle EC, Goumernov BC, McKeown CA, Schatz M, Johns DR, Porter JD, Beggs AH. Oculomotor Nerve and Muscle Abnormalities in Congenital Fibrosis of the Extraocular Muscles. Annals of Neurology. 1997;41:314-25.

INTERNET
Andrews, CV, Desai J, Hunter DG, and Engle EC. (Updated:December 29, 2011). Congenital Fibrosis of the Extraocular Muscles. In: GeneReveiws at GeneTests: Medical Genetics Information Resource (database online). Copyright, University of Washington, Seattle. 1997-2013. Available at http://www.genetests.org Accessed:March 21, 2013.

The information in NORD’s Rare Disease Database is for educational purposes only. It should never be used for diagnostic or treatment purposes. If you have questions regarding a medical condition, always seek the advice of your physician or other qualified health professional. NORD’s reports provide a brief overview of rare diseases. For more specific information, we encourage you to contact your personal physician or the agencies listed as “Resources” on this report.

Report last updated: 2013/03/09 00:00:00 GMT+0

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