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Multiple Endocrine Neoplasia Type 1

Abstract

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NORD is very grateful to Maria Luisa Brandi, MD, PhD, Director, Regional Center for Hereditary Endocrine Tumors, University of Florence, Florence, Italy, for assistance in the preparation of this report.

Synonyms of Multiple Endocrine Neoplasia Type 1

  • MEN-1
  • MEN-1 syndrome
  • multiple endocrine adenomatosis
  • Wermer's syndrome

Disorder Subdivisions

  • No subdivisions found.

General Discussion

Multiple endocrine neoplasia (MEN) type 1 is a rare genetic disorder in which benign (noncancerous) tumors arise from the cells of various glands of the endocrine system. The endocrine system is the network of glands that secrete hormones into the bloodstream where they travel to various areas of the body. These hormones regulate the chemical processes (metabolism) that influence the function of various organs and activities within the body. Hormones are involved in numerous vital processes including regulating heart rate, body temperature and blood pressure as well as cell differentiation and growth and also in modulation of several metabolic processes. In individuals with MEN type 1, benign tumors develop in multiple endocrine glands, most often the parathyroid, pancreas and pituitary glands. These affected glands secrete excessive amounts of hormones into the bloodstream, which can result in a variety of symptoms. Some benign tumors associated with MEN type 1 can become malignant (cancerous). MEN type 1 can run in families or can occur as the result of a new gene mutation in the affected person.

Multiple Endocrine Neoplasia Type 1 Resources

Please note that some of these organizations may provide information concerning certain conditions potentially associated with this disorder.

NORD Member Organizations:

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Other Organizations:

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