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Multiple Endocrine Neoplasia Type 1

NORD is very grateful to Maria Luisa Brandi, MD, PhD, Director, Regional Center for Hereditary Endocrine Tumors, University of Florence, Florence, Italy, for assistance in the preparation of this report.

Synonyms of Multiple Endocrine Neoplasia Type 1

  • MEN-1
  • MEN-1 syndrome
  • multiple endocrine adenomatosis
  • Wermer's syndrome

Disorder Subdivisions

  • No subdivisions found.

General Discussion

Multiple endocrine neoplasia (MEN) type 1 is a rare genetic disorder in which benign (noncancerous) tumors arise from the cells of various glands of the endocrine system. The endocrine system is the network of glands that secrete hormones into the bloodstream where they travel to various areas of the body. These hormones regulate the chemical processes (metabolism) that influence the function of various organs and activities within the body. Hormones are involved in numerous vital processes including regulating heart rate, body temperature and blood pressure as well as cell differentiation and growth and also in modulation of several metabolic processes. In individuals with MEN type 1, benign tumors develop in multiple endocrine glands, most often the parathyroid, pancreas and pituitary glands. These affected glands secrete excessive amounts of hormones into the bloodstream, which can result in a variety of symptoms. Some benign tumors associated with MEN type 1 can become malignant (cancerous). MEN type 1 can run in families or can occur as the result of a new gene mutation in the affected person.

Symptoms

The specific symptoms associated with MEN type 1 depends on which glands are affected by the overgrowth of tissue (hyperplasia) or tumor formation. Although most tumors are benign (noncancerous), tissue overgrowth or tumor formation causes the affected glands to become hyperactive (produce excess hormones). Elevated hormone levels lead to the various symptoms associated with MEN type 1. Certain tumors, such as gastrinomas and carcinoid tumors, can potentially become malignant (cancerous). The clinical expression of MEN-1 is highly variable.

More than 20 different endocrine and non-endocrine tumors have been identified in individuals with MEN type 1. Affected individuals will not necessarily develop benign growths at the same age or in the same locations and, therefore, can develop widely different symptoms. Some individuals may only develop mild symptoms; others may develop serious, life-threatening complications. Some individuals may develop symptoms as young adults or adolescents; other may not develop symptoms until middle-age or older.

It is important to note that individual cases are highly variable and that affected individuals will not develop all of the symptoms discussed below.

PARATHYROID GLANDS
Benign growths associated with MEN type 1 most often affect the parathyroid glands. More than 90 percent of individuals with MEN type 1 eventually develop primary hyperparathyroidism, usually by age 50. In some cases, hyperparathyroidism may be detected by age 20. The parathyroid glands are generally represented by four very small glands (approximately the size of a pea) located in the neck that secrete parathyroid hormone, which helps regulate the amount of calcium in the body. Hyperparathyroidism is the medical term for when there is too much parathyroid hormone in the body.

Hyperparathyroidism can be very mild and may not cause any obvious symptoms (asymptomatic), but is the first symptom noted in 90 percent of cases of MEN type 1. Hyperparathyroidism generally results in too much calcium building up in the blood (hypercalcemia), which can eventually cause kidney stones or damage the kidneys. Hyperparathyroidism can cause additional symptoms in some cases including fatigue, weakness, constipation, nausea, ulcers, indigestion, high blood pressure (hypertension), and muscle or bone pain. Central nervous system abnormalities can eventually develop including mental status changes, lethargy, depression, and confusion. Some individuals may develop abnormal thinning of bones (osteoporosis), which can result in an increased risk of fractures. Most individuals with hyperparathyroidism do not develop all of these symptoms, especially when the condition is diagnosed early.

PANCREAS AND DUODENUM
Approximately 40 percent of adults with MEN type 1 developed multiple gastrinomas, usually located in the first portion of duodenum in MEN1 patients. Approximately, 50% of MEN1-gastrinomas have already metastasized at clinical diagnosis. The pancreas is a small gland located behind the stomach. It contains specialized endocrine cells called islet cells, which secrete several hormones including insulin (which lowers blood sugar levels), glucagon (which raises blood sugar levels), and hormones that travel to the intestines and aid in digestion such as gastrin. The duodenum is the first portion of the small intestine, which connects the intestines to the stomach.

Gastrinomas are benign tumors that secrete gastrin. Elevated levels of gastrin causes the stomach to release too much acid, which, in turn, can result in abdominal pain, diarrhea, backflow of the contents of the stomach into the esophagus (esophageal reflux), and peptic ulcers (clinically referred to as Zollinger-Ellison syndrome). Peptic ulcers are open sores lining the stomach, esophagus, and intestines. Peptic ulcers can cause a burning pain in the stomach, diarrhea, nausea, vomiting and fatty, smelly stools. In severe cases, peptic ulcers can cause serious complications including internal bleeding, vomiting up of blood, obstruction of the passage of food through the digestive tract (gastric outlet obstruction) or the development of a hole in the wall of the stomach or small intestines (perforation), allowing the contents of the stomach or intestines to leak into the abdomen.

Less common symptoms associated with gastrinomas include unintended weight loss and heartburn. Gastrinomas and other tumors that arise from islet cells can potentially become malignant and spread (metastasize) to other areas of the body, especially nearby lymph nodes and the liver.

Multiple gastrinomas are also found in a nonsyndromic disorder called Zollinger-Ellison syndrome, which usually occurs randomly for unknown reasons.

PITUIARY GLAND
Approximately 25 percent of individuals with MEN type 1 develop benign growths of the pituitary gland. In some cases, symptoms of pituitary gland involvement may be the first sign of the disorder. The pituitary is small pea-sized gland that sits in the base of brain and is sometimes called "the master gland" because it oversees the function of most of the endocrine glands in the body. The pituitary gland secretes a variety of different hormones including prolactin, which influences fertility and stimulates breast milk production; growth hormone, which regulates body growth especially during adolescence; and several hormones that stimulate the activity of other glands including the adrenal and thyroid glands and ovaries and testes.

Benign tumors that secrete prolactin (prolactinomas) are the most common pituitary gland tumor associated with MEN type 1. They are the third most common tumor associated with MEN type 1 after parathyroid tumors and gastrinomas. In women, prolactinomas can cause irregular menstrual periods (oligomenorrhea to amenorrhea), infertility, diminished sexual drive, painful intercourse and the production of breast milk in women who are not pregnant (galactorrhea). The most common clinical manifestations in males are impotence and gynecomastia.

Pituitary tumors, especially when more than 1 centimeter in diameter (macrodenoma), can result in additional symptoms because they can apply pressure upon other tissues of the brain. Resulting symptoms may include headaches and visual problems such as blurred vision.

CARCINOID TUMORS
Approximately 10-15 percent of individuals with MEN type 1 will develop slow-growing carcinoid tumors. These tumors usually develop in the stomach (gastric carcinoids), the large tubes that carry air to and from the lungs (bronchial tubes) (bronchial carcinoids) and the thymus (thymic carcinoid), a small gland located in the upper chest just behind the breastbone. Carcinoid tumors of the bronchial tubes primarily affect women; carcinoid tumors of the thymus primarily affect men.

In most cases, these tumors do not produce hormones (non-functioning tumors) and usually do not cause any symptoms (asymptomatic). In rare cases, carcinoid tumors may overproduce different hormones including ACTH, calcitonin, growth hormone releasing hormone (GHRH), serotonin, and histamine. When carcinoid tumors secrete serotonin, they can cause carcinoid syndrome, a condition characterized by migraines, diarrhea and episodes of feeling flushed.

Carcinoid tumors associated with MEN type I are usually identified later during life, with a mean diagnosis of age 50. These tumors may be benign, but malignant (cancerous) carcinoids can develop. Thymic carcinoids associated with MEN type 1 may be particularly aggressive, especially in male smokers.

ADDITIONAL BENIGN ENDOCRINE TUMORS
Additional tumors can affect the pancreas and the pituitary gland. An insulinoma, a benign tumor that secretes insulin, is the second most common tumor affecting the pancreas, occurring in approximately 10 percent of individuals with MEN type 1. An insulinoma can cause low blood sugar (hypoglycemia) especially when not eating over a period of time (fasting). Hypoglycemia can cause a variety of symptoms including confusion, abnormal behavior, blurred vision, double vision, anxiety, heart palpitations, sweating and hunger.

Tumors that secrete too much glucagon or somatostatin (glucagonomas and somatostatinomas) can also occur. These tumors result in elevated levels of blood sugar (hyperglycemia). Hyperglycemia can cause diabetes.

In rare cases, individuals with MEN type 1 can develop a VIPoma, a tumor that secretes a hormone called vasoactive intestinal peptide (VIP). VIPomas can cause chronic, watery diarrhea and eventually cause dehydration. In approximately 40 percent of cases, non-functioning pancreatic tumors may occur in MEN1 patients.

In addition to a prolactinoma, other tumors affecting the pituitary gland may occur. One of these tumors can secrete excess growth hormone resulting in a condition characterized by excessive bone growth and enlargement of certain structures of the body such as the jaw, hands and feet (acromegaly) in postpuberal patients. Another of these tumors may secrete adrenocorticotrophin (ACTH), a hormone that stimulates the adrenal glands, which results in excessive corticosteroid production. Excessive corticosteroid levels can eventually cause a condition called Cushing’s syndrome which is characterized by a wide variety of signs and symptoms including a rounded face (moon face), increased fat around the neck, weight gain around the midsection and upper back, muscle weakness, fatigue and high blood pressure.

Affected individuals may also have benign tumors that do not produce any hormones (non-functioning tumors). In approximately 20-40 percent of cases non-functioning tumors of the adrenal glands may occur. The adrenal glands are located on top of the kidneys. In rare cases, these tumors result in the overproduction of corticosteroid hormones and the development of Cushing’s syndrome.

In extremely rare cases, = 1%, a pheochromocytoma may occur in an individual with MEN type 1. Most pheochromocytomas originate in the inner layer (medulla) of one of the two adrenal glands. Symptoms may include high blood pressure, headaches, excessive sweating, and heart palpitations. Pheochromocytomas occur much more often in individuals with multiple endocrine neoplasia type 2.

NON-ENDOCRINE BENIGN TUMORS
Several tumors that do not arise from endocrine cells may occur in individuals with MEN type 1. The most common is a lipoma, a benign tumor consisting of fat cells. Lipomas usually develop just under the surface of the skin and are common in the general population. Multiple lipomas often form. Lipomas are not usually associated with any symptoms. Some individuals with MEN type 1 may also develop benign raised, reddish spots on the face (angiofibromas), and benign, raised, whitish spots on the skin (collagenomas).

Less common, non-endocrine, benign tumors associated with MEN type I include tumors arising from the membranes (meninges) lining the brain and spinal cord (meningioma), tumors arising from smooth muscle cells (leiomyoma) and tumors arising from central nervous system tissue (ependymomas). These tumors generally do not cause any symptoms.

Causes

MEN type I is a rare genetic disorder caused by disruption or changes (mutation) of the MEN1 gene. This genetic mutation may be inherited as an autosomal dominant trait or occur as a new gene mutation in the affected person.

Chromosomes, which are present in the nucleus of human cells, carry the genetic information for each individual. Pairs of human chromosomes are numbered from 1 through 22 (autosomal chromosomes), and an additional 23rd pair of sex chromosomes which include one X and one Y chromosome in males and two X chromosomes in females. Each chromosome has a short arm designated "p" and a long arm designated "q". Chromosomes are further sub-divided into many bands that are numbered. For example, "chromosome 11q13" refers to band 13 on the long arm of chromosome 11. The numbered bands specify the location of the thousands of genes that are present on each chromosome.

Autosomal dominant genetic diseases are determined by the combination of genes for a particular trait that are on the autosomal chromosomes received from the father and the mother. Dominant genetic disorders occur when only a single copy of an abnormal gene is necessary for the appearance of the disease. The abnormal gene can be inherited from either parent, or can be the result of a new mutation (gene change) in the affected individual. The risk of passing the abnormal gene from affected parent to offspring is 50 percent for each pregnancy regardless of the sex of the resulting child.

Investigators have determined that the MEN1 gene is located on the long arm (q) of chromosome 11 (11q13). The MEN1 contains instructions for creating (encoding) a protein known as menin. The exact role of menin is not fully understood. The MEN1 gene is believed to be a tumor suppressor gene, a gene that when it operates normally may have several functions including inhibiting cell division, repairing and replicating DNA, and instructing cells when to die (a normal process called apoptosis). When tumor suppressor genes malfunction, certain cells may continue to grow and reproduce causing tumor formation.

Affected Populations

MEN type I affects males and females in equal numbers. It affects approximately 1 in 30,000 individuals. Some researchers believe that many cases of MEN type 1 go undiagnosed, making it difficult to determine its true frequency in the general population. The onset of the disorder can vary widely and it has been identified in children as young as 8 and adults as old as 80. MEN type 1 was first recognized as a genetic disorder in 1954.

Related Disorders

Symptoms of the following disorders can be similar to those of MEN type I. Comparisons may be useful for a differential diagnosis.

Multiple endocrine neoplasia type 2 (MEN type 2) is a rare genetic disorder characterized by tissue overgrowth or tumor formation in various endocrine glands including the thyroid, the adrenal glands and the parathyroid. MEN type 2 is further classified into three distinct subtypes, MEN type 2A, MEN type 2B and familial medullary thyroid cancer (FMTC). All three subtypes of MEN type 2 carry an increased risk of developing a specific form of thyroid cancer called medullary carcinoma. Individuals with MEN type 2A also have an increased risk of developing benign tumors of the parathyroid (adenomas) and the adrenal glands (pheochromocytomas). MEN type 2A is associated with pheochromocytomas, multiple tumors of nerve tissue (neuromas), and multiple nerve cell tumors (ganglioneuromatosis) in the gastrointestinal tract. MEN type 2 can run in families or can occur as the result of a new gene mutation in the affected person. MEN type 2 is caused by mutation of the RET gene. (For more information on this disorder, choose "multiple endocrine neoplasia type 2" as your search term in the Rare Disease Database.)

The various tumors associated with MEN type 1 can occur as isolated conditions or as part of other disorders including familial isolated hyperparathyroidism, hereditary hyperparathyroidism-jaw tumor syndrome, MEN4, von Hippel-Lindau syndrome, Carney complex, and Zollinger-Ellison syndrome. When these tumors secrete excessive hormones into the bloodstream a variety of different conditions can result including hyperparathyroidism, hyperprolactinemia, acromegaly, Cushing’s syndrome, hypoglycemia, hyperglycemia, and carcinoid syndrome. (For more information on these disorders, choose the specific disorder name as your search term in the Rare Disease Database.)

Standard Therapies

Diagnosis
Affected individuals may receive a diagnosis of MEN type 1 following a thorough clinical evaluation, a detailed patient and family history and the identification of at least two of the three characteristic endocrine tumors associated with the disorder (i.e., parathyroid and pituitary tumors and islet cell tumors in the pancreas or duodenum). Individuals with only one of the associated tumors and/or a known MEN1 gene mutation may also receive a diagnosis of MEN type 1 if there is a positive family history of the disorder. A variety of tests to detect elevated levels of certain hormones in the blood may be necessary to aid in the identification of tumors. For example, identification of elevated levels of parathyroid hormone together with hypercalcemia can indicate the presence of a parathyroid tumor. A variety of imaging scans may be performed to aid in identifying the size and location of specific tumors.

A diagnosis of MEN type 1 can be confirmed through molecular genetic testing, which can reveal the characteristic mutation of the MEN1 gene that causes the disorder. Molecular genetic testing is available on a clinical basis. Genes to be tested are the MEN1
gene. Very rarely the p27 gene can be found mutated.

Treatment
The treatment of MEN type 1 may require the coordinated efforts of a team of specialists. Endocrinologists, surgeons, cancer specialists (oncologists), and other healthcare professionals may need to systematically and comprehensively plan an affect child’s treatment. Treatment is directed toward the specific symptoms that are apparent in each individual and may include surgical removal of tumors, drugs to counteract the effects of excess hormones, and chemotherapy or radiation therapy (radiotherapy) to help shrink or destroy tumors.

Specific therapeutic procedures and interventions may vary depending upon numerous factors, such as primary tumor location; the size and type of tumor; the severity of symptoms due to excess hormone production; whether malignant tumors are present and whether they have spread to lymph nodes or distant sites; individual’s age and general health; and/or other elements. Decisions concerning the use of particular interventions should be made by physicians and other members of the health care team in careful consultation with the patient, based upon the specifics of his or her case; a thorough discussion of the potential benefits and risks; patient preference; and other appropriate factors.

The main treatment for parathyroid tumors is surgery, although the best type of surgery and the best time for surgery is still controversial. Surgical removal of the parathyroid glands is called a parathyroidectomy. One approach is to remove three parathyroid glands entirely and a portion of the fourth (subtotal parathyroidectomy). There is a 50 percent risk that of recurrence of a parathyroid tumor with this method. Another approach is to remove all four glands (total parathyroidectomy). This procedure is usually followed by the transplantation of some of the apparently healthy parathyroid tissue into another area of the body (usually the nondominant forearm). Because of the high risk of disease recurrence, this would spare affected individuals from being operated on in the same area (i.e., the neck). In some cases, healthy parathyroid tissue is saved through cryopreservation (the process of cooling and storing tissue) and re-implanted at a later date. Very recently, preliminary studies suggest possible future opportunities for nonsurgical options in the treatment of MEN1-associated primary hyperparathyroidism, using cinacalcet.

Surgical removal of part or all of the parathyroid glands may result in hypoparathyroidism (low levels of parathyroid hormones in the blood). Hypoparathyroidism can result in low levels of calcium in the body. Affected individuals may require daily supplementation of calcium and vitamin D to prevent the effects of hypoparathyroidism.

Pituitary tumors that secrete prolactin (prolactinomas) may be treated with dopamine agonists, drugs that lower the levels of prolactin in the blood and shrink pituitary tumors. Some prolactinomas are small enough that no therapy is required. In cases where drug therapy is ineffective or cannot be tolerated, surgical removal of the tumor(s) may be required.

Pituitary tumors that produce growth hormone may be treated with transsphenoidal surgery, a procedure in which surgeons go through the cavity (sphenoid sinus) directly behind the nose. Radiotherapy may be required to destroy any remaining tumor tissue that could not be removed surgically. Certain drugs such as octreotide and lanreotide may be used to treat individuals with tumors that produce growth hormones. These drugs are called somatostatin analogs and are similar in make up to somatostatin, a hormone naturally found in the body that signals the pituitary gland to stop making growth hormone.

Pituitary tumors that produce ACTH are usually treated by transsphenoidal surgery. Radiotherapy may also be necessary for tumors that cannot be completely removed by surgery.

Treatment for tumors that secrete gastrin (gastrinomas) remains controversial. Surgical removal of a solitary gastrinoma is often successful. However, because gastrinomas in MEN type 1 are often small, numerous and spread out mainly through duodenum, surgery is extremely difficult and it needs to be performed by a highly skilled surgery team. The main form of therapy for gastrinoma-induced abnormalities is the use of medications that can reduce acid production such as proton pump inhibitors and H2-receptor blockers. These drugs are effective in preventing the serious complications potentially associated with gastrinomas such as severe peptic ulcer disease. The drug octreotide may be used as it also reduces gastrin and acid levels.

Other tumors of the pancreas and duodenum may be treated surgically. Insulinomas are usually surgically removed if they cause hypoglycemia. If the tumor cannot be completely removed by surgery, the drug diazoxide may alleviate hypoglycemia by inhibiting the production of insulin.

Carcinoid tumors are generally removed surgically. Medications including octreotide and lanreotide can be used to treat excess hormone production from these tumors, but the risk for malignant transformation remains. For this purpose, removal of thymus, through a transcervical approach, is recommended at the time of neck surgery for parathyroidectomy.

Lipomas may be removed surgically. Genetic counseling may be of benefit for affected individuals and their families. Other treatment is symptomatic and supportive.

Investigational Therapies

Information on current clinical trials is posted on the Internet at www.clinicaltrials.gov. All studies receiving U.S. Government funding, and some supported by private industry, are posted on this government web site.

For information about clinical trials being conducted at the NIH Clinical Center in Bethesda, MD, contact the NIH Patient Recruitment Office:

Tollfree: (800) 411-1222
TTY: (866) 411-1010
Email: prpl@cc.nih.gov

For information about clinical trials sponsored by private sources, contact:
www.centerwatch.com

Contact for additional information about multiple endocrine neoplasia type 1:

Maria Luisa Brandi, MD, PhD
Center for Hereditary Endocrine Tumors
University of Florence
Viale Pieraccini 6
50139 Florence, Italy
Phone: 39 337685511
Fax: 39 0552337867
Email: m.brandi@dmi.unifi.it
info@fondazionefirmo.com

Organizations related to Multiple Endocrine Neoplasia Type 1

Please note that some of these organizations may provide information concerning certain conditions potentially associated with this disorder.

References

TEXTBOOKS
Gagel RF, Marx SJ. Multiple Endocrine Neoplasia. In: Larsen PR, Kronenberg HM, Melmed S, Polonsky KS. eds. Williams Textbook of Endocrinology. 10th ed. Philadelphia, PA: Elsevier Saunders; 2003:1717-1762.

Berkow R., ed. The Merck Manual-Home Edition. 2nd ed. Whitehouse Station, NJ: Merck Research Laboratories; 2003:972-974.

Rimoin D, Connor JM, Pyeritz RP, Korf BR. Eds. Emory and Rimoin’s Principles and Practice of Medical Genetics. 4th ed. New York, NY: Churchill Livingstone; 2002:2209-2213.

JOURNAL ARTICLES
Luzi E, Marini F, Tognarini I, Galli G, Falchetti A, Brandi ML. The Regulatory Network Menin-MicroRNA 26a as a Possible Target for RNA-Based Therapy of Bone Diseases. Nucleid Acid Ther. 2012;22:103-8.

Giudici F, Nesi G, Brandi ML, Tonelli F. Surgical management of insulinomas in multiple endocrine neoplasia type 1. Pancreas. 2012;41:547-53.

Brandi Ml, Tonelli F. Introduction to the 12th International Workshop on Multiple Endocrine Neoplasia. Endocr Pract. 2011;17(suppl 3):1.

Saggini A, Brandi ML. Skin lesions in hereditary endocrine tumor syndromes. Endocr Pract. 2011;17(suppl 3):47-57.

Luzi E, Brandi ML. Are microENAs involved in the endocrine-specific pattern of tumorigenesis in multiple endocrine neoplasia type 1? Endocr Pract. 2011;17(suppl 3):58-63.

Tonelli F, Giudici F, Fratini G, Brandi ML. Pancreatic endocrine tumors in multiple endocrine neoplasia Type 1 syndrome: review of literature. Endocr Pract. 2011;17(suppl 3):33-40.

Brandi ML. Parathyroid gland: Hyperparathyroidism in MEN1 syndrome: time to operate? Nat Rev Endocrinol. 2010;6:604-5.

Luzi E, Marini F, Tognarini I, et al. Rimbozyme-mediated compensatory induction of menin-oncosuppressor function in primary fibroblasts from MEN1 patients. Cancer Gene Ther. 2010;17:814-25.

Falchetti A, Cilotti A, Vaggelli L, et al. A patient with MEN1-associated hyperparathyroidism, responsive to cinacalcet. Nat Clin Pract Endocrinol Metab. 2008;4(6):351-7.

Faggiano A, Tavares LB, Tauchmanova L, et al. Effect of treatment with depot somatostatin analogue octreotide on primary hyperparathyroidism (PHP) in multiple endocrine neoplasia type 1 (MEN1) patients. Clinical Endocrinology. 2008;69:756-762.

White ML, Doherty GM. Multiple endocrine neoplasia. Surg Oncol Clin N Am. 2008;17:439-459.

Falchetti A, Marini F, Luzi E, Tonelli F, Brandt ML. Multiple endocrine neoplasms. Best Pract Res Clin Rheumatol. 2008;22:149-163.

Pellegata NS, Quintanilla-Martinez L, Siggelkow H, et al. Germ-line mutations in p27Kip1 cause a multiple endocrine neoplasia syndrome in rats and humans. Proc Natl Acad Sci USA. 2006;103:15558-63.

Busygina V, Bale AE. Multiple endocrine neoplasia type 1 (MEN1) as a cancer predisposition syndrome: clues into the mechanisms of MEN1-related carcinogenesis. Yale J Biol Med. 2006;79:105-114.

Lambert LA, Shapiro SE, Lee JE, et al. Surgical treatment of hyperparathyroidism in patients with multiple endocrine neoplasia type 1. Arch Surg. 2005;40:374-382.

Tonelli F, Fratini G, Falchetti A, Nesi G, Brandi ML. Surgery for gastroenteropancreatic tumours in multiple endocrine neoplasia type 1: review and personal experience. J Intern Med. 2005;257:38-49.

Ramage JK, Davies AHG, Ardill J, et al. Guidelines for the management of gastroenteropancreatic neuroendocrine (including carcinoid) tumours. Gut. 2005;54:1-16.

Falchetti A, Marini F, Brandi ML. Multiple Endocrine Neoplasia Type 1. Gene Reviews. 1993-2005.

Kouvaraki MA, Lee JE, Shapiro SE, et al. Genotype-phenotype analysis in multiple endocrine neoplasia type 1. Arch Surg. 2002;137:641-647.

Brandi ML, Gagel RF, Angeli A, et al. Guidelines for the diagnosis and therapy of MEN type 1 and type 2. J Clin Endocrinol Metab. 2001;86:5658-5671.

Norton JA, Alexander HR, Fraker DL, et al. Comparison of surgical results in patients with advanced and limited disease with multiple endocrine neoplasia type 1 and Zollinger-Ellison syndrome. Ann Surg. 2001;234:495-505.

Bystrom C, Larsson C, Blomberg C, et al. Localization of the MEN1 gene to a small region with chromosome 11q13 by deletion mapping in tumors. Proc Natl Acad Sci USA. 1990;87:1968-1972.

INTERNET
Falchetti A, Marini F, Brandi ML. (Updated March 2, 2010). Multiple Endocrine Neoplasia Type 1. In: GeneReviews at GeneTests: Medical Genetics Information Resource (database online). Copyright, University of Washington, Seattle. 1997-2011. Available at http://www.genetests.org. Accessed May 3, 2012.

Diaz-Thomas A. Pediatric Multiple Endocrine Neoplasia. Emedicine. http://emedicine.medscape.com/article/923269-overview. Updated April 19, 2012. Accessed May 3, 2012.

Marini F, Falchetti A, Del Monte F, et al. Multiple Endocrine Neoplasia Type 1. Orphanet encyclopedia.http://www.ojrd.com/content/pdf/1750-1172-1-38.pdf. October 2, 2006. Accessed May 3, 2012.

Online Mendelian Inheritance in Man (OMIM). The Johns Hopkins University. Multiple Endocrine Neoplasia, Type I; MEN1. Entry No: 131100. Last Edited October 11, 2011. Available at: http://www.ncbi.nlm.nih.gov/omim/. Accessed May 3, 2012.

The information in NORD’s Rare Disease Database is for educational purposes only. It should never be used for diagnostic or treatment purposes. If you have questions regarding a medical condition, always seek the advice of your physician or other qualified health professional. NORD’s reports provide a brief overview of rare diseases. For more specific information, we encourage you to contact your personal physician or the agencies listed as “Resources” on this report.

Report last updated: 2012/05/07 00:00:00 GMT+0

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