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Chronic Eosinophilic Pneumonia

Abstract

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NORD is very grateful to Nausherwan K. Burki, MD, PhD, University of Connecticut Health Center, for assistance in the preparation of this report.

Synonyms of Chronic Eosinophilic Pneumonia

  • Carrington's disease
  • CEP
  • ICEP
  • idiopathic chronic eosinophilic pneumonia

Disorder Subdivisions

  • No subdivisions found.

General Discussion

Summary
Chronic eosinophilic pneumonia (CEP) is a rare disorder characterized by the massive accumulation of eosinophils in the lungs (pulmonary eosinophilia). Eosinophils are a type of white blood cell and are part of the immune system. They are usually produced in response to allergens, inflammation or infection (especially parasitic ones) and are particularly active in the respiratory tract. In CEP, eosinophils also accumulate in the bloodstream (peripheral eosinophilia). Common symptoms include shortness of breath (dyspnea), cough, fatigue, night sweats, low grade fevers, and unintended weight loss. The exact cause of CEP is unknown (idiopathic).

Introduction
CEP was first described as a distinct entity in the medical literature by Carrington, et al. in 1969 when they described nine individuals with the disorder. It is classified as a form of eosinophilic lung disease, a large group of interstitial lung diseases. CEP is different from acute eosinophilic pneumonia (AEP), which is marked by rapid onset, the absence of asthma, a greater potential for acute respiratory failure and no relapse following treatment. For more information on AEP, choose "acute eosinophilic pneumonia" as your search term in the Rare Disease Database.

Organizations related to Chronic Eosinophilic Pneumonia

Please note that some of these organizations may provide information concerning certain conditions potentially associated with this disorder.

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