CLOVES Syndrome

Abstract

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NORD is very grateful to Ahmad I. Alomari, MD, MSc, FSIR, Associate Professor; Program Director, Pediatric Vascular and Interventional Radiology Fellowship; Co-Director, Vascular Anomalies Center, Children's Hospital Boston, for the preparation of this report.

Synonyms of CLOVES Syndrome

• CLOVE syndrome
• CS

Disorder Subdivisions

• No subdivisions found.

General Discussion

Summary
CLOVES syndrome (CS) is a recently described rare disorder characterized by tissue overgrowth and complex vascular anomalies. CLOVES stands for congenital lipomatous (fatty) overgrowth, vascular malformations, epidermal nevi and scoliosis/skeletal/spinal anomalies.

Introduction
CLOVES syndrome was described independently by Saap and colleagues in 2007 and Alomari in 2009. A case report by the German physician Hermann Friedberg "gigantism of the right lower limb" published in 1867 is probably the first known written account of CLOVES syndrome.

Organizations related to CLOVES Syndrome

• CLOVES Syndrome Community
  • PO Box 406
  • West Kennebunk, ME 04094
  • Phone #: (20-7) -281-2130
  • 800 #: N/A
  • e-mail: clovessyndrome@gmail.com
  • Home page: http://www.clovessyndrome.org
• Genetic and Rare Diseases (GARD) Information Center
  • PO Box 8126
  • Gaithersburg, MD 20898-8126
  • Phone #: 301-251-4925
  • 800 #: 888-205-2311
  • e-mail: N/A
  • Home page: http://rarediseases.info.nih.gov/GARD/
• National Organization of Vascular Anomalies
  • PO Box 38216
  • Greensboro, NC 27438-8216
  • Phone #: N/A
  • 800 #: N/A
  • e-mail: admin@mail.novanews.org
  • Home page: http://www.novanews.org

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Copyright 2012

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