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Hereditary Leiomyomatosis and Renal Cell Carcinoma

Abstract

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NORD is very grateful to Eamonn R. Maher, MD, FRCP, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, Medical and Molecular Genetics, IBR, University of Birmingham, for assistance in the preparation of this report.

Synonyms of Hereditary Leiomyomatosis and Renal Cell Carcinoma

  • HLRCC
  • Reed’s Syndrome

Disorder Subdivisions

  • No subdivisions found.

General Discussion

Summary
Hereditary leiomyomatosis and renal cell carcinoma, also known as HLRCC, is a rare genetic disorder characterized by smooth muscle growths (leiomyomas) on the skin and uterus and an increased risk of developing kidney (renal) cancer. Skin growths may appear as appear as small, firm bumps (papules) or tiny lumps (nodules) and are not cancerous (benign). Uterine leiomyomas, also known as uterine fibroids, may be numerous and are also benign, but can cause symptoms such as heavy menstrual periods or pelvic pressure or pain. Affected individuals are at an increased risk of developing kidney cancer, particularly a form known as type II papillary renal cell carcinoma. Kidney cancer associated with HLRCC is cancerous (malignant) and can be aggressive and spread (metastasize) to other areas of the body. HLRCC is caused by mutations in the fumarate hydratase (FH) gene and is inherited as an autosomal dominant trait.

Introduction
HLRCC is classified as a hereditary renal cancer syndrome, a group of disorders characterized by a genetic predisposition to renal cancer along with other symptoms. There are at least 10 identified hereditary renal cancer syndromes including Von-Hippel-Lindau disease, Birt-Hogg-Dube syndrome, and hereditary papillary renal cell carcinoma. The association of leiomyomas and uterine fibroids as a genetic disorder was first described in the medical literature by Dr. Reed in 1973 and subsequently termed multiple cutaneous and uterine leiomyoma (MCUL) or Reed’s syndrome. The additional association with renal carcinoma was not established until 2001 (Launonen et al.).

Hereditary Leiomyomatosis and Renal Cell Carcinoma Resources

Organizations:

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