Chediak Higashi Syndrome
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NORD is very grateful to Abdulaziz AlGhonaim, MBBS, MD, ABP, Section Head of Pediatric Allergy/ Immunology, Department of Pediatrics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia, for assistance in the preparation of this report.
Synonyms of Chediak Higashi Syndrome
- Begnez-Cesar's Syndrome
- Chediak-Steinbrinck-Higashi Syndrome
- Leukocytic Anomaly Albinism
- Natural Killer Lymphocytes, Defect in
- Oculocutaneous Albinism, Chediak-Higashi Type
- No subdivisions found.
Chediak-Higashi syndrome (CHS) is a rare, inherited, complex, immune disorder of childhood (usually) characterized by abnormally pale skin and eyes (oculocutaneous albinism). Because the patient's white blood cells (leukocytes) are profoundly affected, especially in their capacity to transport cellular proteins, immune disorders are common, along with an increased susceptibility to infections. In addition, CHS patients tend to bruise and bleed easily. Neurological deficits are also common.
CHS is transmitted as an autosomal recessive trait.
Chediak Higashi Syndrome Resources
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