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Pseudoxanthoma Elasticum (PXE)

NORD is very grateful to Mark Lebwohl, MD, Professor and Chairman, Department of Dermatology, The Mount Sinai School of Medicine, for assistance in the preparation of this report.

Synonyms of Pseudoxanthoma Elasticum (PXE)

  • elastosis dystrophica syndrome (obsolete)
  • Gronblad-Strandberg syndrome
  • systemic elastorrhexis (obsolete)

Disorder Subdivisions

  • No subdivisions found.

General Discussion

Pseudoxanthoma elasticum, PXE, is an inherited disorder caused y mutations in the ABCC6 transporter gene that affects connective tissue in some parts of the body. Elastic tissue in the body becomes mineralized; that is, calcium and other minerals are deposited in the tissue. This can result in changes in the skin, eyes, cardiovascular system, and gastrointestinal system. Clinicians first recognized PXE more than 100 years ago. Researchers have made a number of significant advances in the past few years.

Symptoms

PXE results in a variety of signs and symptoms that vary in their number, type, and severity from person to person. Certain effects of PXE can cause serious medical problems, while others have less impact. Effects may include: skin changes, changes in the retina of the eye that may result in significant loss of central vision, changes in the cardiovascular system that may involve calcification of arteries and decreased blood flow in the arms and legs, and/or changes in the gastrointestinal system that may lead to bleeding in the stomach or intestines. At present, there is no way to predict the exact progression of the disorder for a particular individual. Some people have no skin lesions; others have no vision loss. Many people do not experience gastrointestinal complications or cardiovascular difficulties. A few have no manifestations of PXE except for a positive skin biopsy or angioid (resembling a blood vessel) streaks in the retina of the eye. The effects of PXE and its rate of progression seem to have no discernible pattern.

Skin: PXE often causes visible changes in the skin. These changes vary from person to person. The earliest changes tend to be in the skin on the sides of one's neck. Small lesions may develop. They may resemble a rash or have a "cobblestone" appearance. These lesions in the skin tend to progress slowly and unpredictably from the neck downward. Skin changes have often been reported in young children. The areas of the body that are most affected are those that bend and flex. The neck, the underarms, the skin on the inside of the elbows, the groin, and the skin behind the knees may be progressively affected, leading to loose folds in these areas. Lesions may appear on the inside of the lower lip or lining of the rectum or vagina. Some of these effects may be alleviated by reconstructive, or plastic, surgery.

It is possible to have PXE and not have any apparent skin lesions. In some individuals, careful examination of the skin by a dermatologist does not reveal any visible sign of lesions, but a positive biopsy indicates the diagnosis of PXE. Since the identification of mutations in the ABCC6 transporter gene as the cause of PXE, analysis of blood can be performed in research centers to confirm the presence or absence of mutations.

Eyes: PXE affects the retina of the eye. The first changes, visible only during an ophthalmologic examination, are called "peau d'orange" because the retina begins to resemble the skin of an orange. This does not affect vision and neither do characteristic irregular streaks, called angioid streaks that develop later. These streaks occur when mineralization of the highly elastic membrane behind the retina, called Bruch's membrane, leads to cracking. Small blood vessels beneath this layer take advantage of these breaks in the membrane and grow through the membrane. This is called neovascularization. Sometimes, these blood vessels leak and bleed. This bleeding results in the loss of central vision. While people with PXE may lose so much vision that they become legally blind, almost all people with PXE continue to have peripheral vision.

People who have PXE can use a tool called an Amsler grid to monitor their central vision. If there is swelling or bleeding in the center of the retina, this may cause the intersecting lines of the Amsler grid to appear distorted. A retinal specialist can instruct a patient in the use of an Amsler grid.

Cardiovascular system: Because PXE can cause mineralization and narrowing of blood vessels, affected individuals may experience cramping in the legs when they are walking, due to decreased blood flow. This decreased flow of blood is called intermittent claudication. Decreased flow of blood to the arms and legs may mean that one's pulse can no longer be felt in the wrists or feet. Some clinicians believe that hypertension (high blood pressure) and mitral valve prolapse may be more common among people with PXE than in the general population. However, these concerns have not been substantiated with large studies. Individuals with PXE should make periodic visits to their physician for monitoring of blood pressure, cholesterol, and pulses in the arms and legs. A heart-healthy lifestyle is recommended, with low-fat foods and plenty of exercise. Consistent exercise may decrease the effects of PXE on the blood vessels. Maintaining normal weight may also be beneficial. Smoking should be avoided.

Gastrointestinal system: Uncommonly, PXE may cause gastrointestinal bleeding. This is sometimes not recognized immediately and can be life-threatening. Little is known about the gastrointestinal effects of PXE, except that the bleeding is usually widespread in the stomach and/or intestines. In a few cases, this bleeding is mistaken for ulcers. A person with PXE experiencing any gastrointestinal difficulty should be sure to tell the attending physician that he or she has PXE. Some physicians recommend that affected individuals avoid non-steroidal, anti-inflammatory medications, such as aspirin, ibuprofen, and naproxen.

Pregnancy: It is thought that most women with PXE have normal pregnancies and that the incidence of pregnancy-related complications is similar to that of the general population. However, for some, gastric or intestinal complications have been reported. In general, complications affecting the fetus have not been reported. There are no prenatal tests to determine whether the fetus has PXE.

Causes

PXE is an inherited disorder. Most often PXE is inherited in a recessive pattern and has been attributed to mutations in the ABCC6 transporter gene.In recessive disorders, the condition does not occur unless an individual inherits the same defective gene for the same trait from each parent. If an individual receives one normal gene and one gene for the disease, the person will be a carrier for the disease but usually will not show symptoms. The risk of transmitting the disease to the children of a couple, both of whom are carriers for a recessive disorder, is 25 percent. Fifty percent of their children risk being carriers of the disease, but generally will not show symptoms of the disorder. Twenty-five percent of their children may receive both normal genes, one from each parent. The risk is the same for each pregnancy.

In some instances, autosomal dominant inheritance has been reported in patients with PXE, but it is not clear if the dominant pattern is truly dominant or if it has been reported because, by chance, one parent is an asymptomatic heterozygote carrier of a mutated ABCC6 transporter gene while he second parent has the disorder. In dominant disorders, a single copy of the disease gene (received from either the mother or father) will be expressed "dominating" the other normal gene and resulting in the appearance of the disease. The risk of transmitting the disorder from affected parent to offspring is 50 percent for each pregnancy, regardless of the sex of the child. The risk is the same for each pregnancy.

Since PXE may be present but undiagnosed in other family members, it is recommended that all immediate relatives be screened for PXE by both an ophthalmologist and a dermatologist. The ophthalmologist should look for peau d'orange and angioid streaks. If suspicious for PXE, the dermatologist should take biopsies from the neck, under the arm and inside the elbow of a person suspected of having PXE. These biopsies may be necessary even if the skin doesn't show any visible lesions. Even with a negative biopsy, it is possible that other family members have PXE. PXE affects each individual with great variability. A blood test is available on a research basis to determine whether a person carries the gene.

The PXE gene has been identified. Known as ABC-C6, it is one of a group of genes that transport certain molecules back and forth across cell membranes. It isn't known at this time what molecules ABC-C6 transports, but it is thought that they may play a role in keeping the elastic fibers found in certain body tissues healthy.

Affected Populations

Estimates of the incidence of PXE range from 1 in 100,000 people to 1 in 25,000. However, the true incidence of PXE is not known in any population. It is likely that many individuals with PXE have not been diagnosed, particularly people with mild signs of PXE or those whose signs are not typical.

Related Disorders

Symptoms of the following disorders may be similar to those of Pseudoxanthoma Elasticum. Comparisons may be useful for a differential diagnosis:

Ehlers-Danlos syndrome is a rare inherited connective tissue disorder. It is characterized by the ability of affected individuals to flex their bodies beyond the normal range (articular hypermobility), to abnormally stretch their skin (hyperelasticity of the skin), and widespread tissue fragility (i.e., skin, blood vessels, and other tissues can rupture from even minor trauma). Many forms of Ehlers-Danlos Syndrome are inherited as an autosomal dominant genetic trait, but some forms of the disorder are inherited as either an autosomal recessive or a x-linked recessive genetic trait. (For more information on this disorder, choose "Ehlers-Danlos Syndrome" as your search term in the Rare Disease Database).

Marfan syndrome is an inherited disorder that affects the connective tissues of the heart and blood vessels (cardiovascular system). The musculoskeletal system (ligaments and muscles) is also affected. Major symptoms also include unusual height, large hands and feet, and involvement of the lungs and the eyes. (For more information on this disorder, choose "Marfan Syndrome" as your search term in the Rare Disease Database).

In addition to peudoxanthoma elasticum, other disorders may be characterized by the development of angioid streaks (e.g., Ehlers-Danlos syndrome, sickle cell disease, hemochromatosis, etc.). There are also additional disorders that may have skin changes similar to those associated with pseudoxanthoma elasticum (e.g., solar elastosis, etc.). These disorders usually have other physical and microscopic features that may differentiate them from pseudoxanthoma elasticum. (For more information on these disordere, choose "sickle cell", "hemochromatosis", and/or "connective tissue" as your search term in the Rare Disease Database).

Standard Therapies

Diagnosis
Changes in the skin are usually the earliest sign of PXE and lead to the definitive diagnosis. Although the signs of PXE and the age of onset vary considerably, many people first notice an unusual appearance of their skin, typically on the sides or back of the neck. Small bumps, called lesions, may appear. Some individuals have described these as looking like a rash or an unwashed neck. Usually, a small biopsy of a lesion is done to confirm the diagnosis of PXE. This biopsy requires that a very small piece of skin, the size of a pencil eraser, be taken from the neck, underarm, and/or inside the elbow. The dermatologist sends this sample to a laboratory where a special stain, called a von Kossa stain, is used to detect calcium in the tissue.

Sometimes, changes in the eye are the first noticeable sign of PXE. Early changes in the eye are visible only during an ophthalmological examination. Later symptoms can include loss of central vision. Some people are first diagnosed with PXE when they notice distortion of their vision.

Treatment
A team of medical specialists (for example, an ophthalmologist, dermatologist, gastroenterologist, and primary care physician) may be needed to help manage PXE and its effects. People affected by PXE should be sure that all the health care professionals they visit are well-informed about the possible ramifications of PXE.

Regular physician exams by a knowledgeable primary care physician are necessary. A detailed family history should be taken with regard to onset, signs that may be related to PXE and the rest of the family's medical history. The affected individual's cholesterol and triglycerides should be checked. Peripheral pulses should be monitored, as well. A dermatologist will most likely be the physician to make the definitive diagnosis and offer advice on reconstructive surgery, if that is of interest to the patient. An ophthalmologist will dilate the eyes to look for peau d'orange and angioid streaks. If angioid streaks are found, it may be wise to consult a retinal specialist. A cardiologist can perform a baseline EKG and sonogram test.

In cases that involve retinal hemorrhage, laser treatment or injectible medications have been helpful for some people. However, not everyone can benefit from these treatments. In some cases, laser surgery does not restore vision. In others, scarring from both the bleeding and the laser surgery have made vision worse. A variety of visual aids can be provided to help compensate for loss of vision. A low vision clinic can be helpful in this regard.

It is generally thought that people affected by PXE should avoid activities that might cause direct trauma to the eyes. Activities that increase pressure in the eyes, such as weight lifting, should also be avoided.

Investigational Therapies

At this time, genetic research, including studies to characterize the gene mutations, is being conducted in several labs. Once the mutations have been identified, researchers will be able to study the changes that are caused by PXE and how to correct them or compensate for them.

Other PXE research includes clinical studies to determine what characterizes PXE, how it progresses, and what changes it causes in various systems of the body. In the next few years, it may be possible to determine, through a blood test, whether an individual has PXE.

Retinal research is advancing quickly. There are currently many projects looking at angioid streaks, retinal bleeding and what can be used to alleviate the bleeding and loss of vision that often follows.

Clinical research on PXE is currently being conducted at the following sites:

Lionel Bercovitch, M.D.
International PXE Registry, Epidemiological Study and Blood Bank
Genetic studies, mutational analysis, pathophysiology, MRI study
Department of Dermatology
Providence, RI 02912
Tel: 781-341-0530
E-mail: winnipegjet@earthlink.com

Mark Lebwohl, M.D.
PXE (Pseudoxanthoma Elasticum) Research Project
Department of Dermatology
Mount Sinai School of Medicine
Fifth Avenue & 100th Street
New York, NY 10029
Tel: 212-876-7199

Kenneth H. Neldner, M.D.
Pseudoxanthoma Elasticum (PSE) Research Program
Department of Dermatology
Health Sciences Center
Texas Tech University
Lubbock, TX 79430
Tel: 806-743-2456

Information on current clinical trials is posted on the Internet at www.clinicaltrials.gov. All studies receiving U.S. Government funding, and some supported by private industry, are posted on this government web site.

For information about clinical trials being conducted at the NIH Clinical Center in Bethesda, MD, contact the NIH Patient Recruitment Office:

Tollfree: (800) 411-1222
TTY: (866) 411-1010
Email: prpl@cc.nih.gov

For information about clinical trials sponsored by private sources, contact:
www.centerwatch.com

Pseudoxanthoma Elasticum (PXE) Resources

Organizations:

References

TEXTBOOKS
Kanski JJ, ed. Clinical Ophthalmology, 4th ed. Woburn, MA: Butterworth-Heinemann; 1999:431-32.

Bennett JC, Plum F. eds. Cecil Textbook of Medicine. 20th ed. Philadelphia, PA: W.B. Saunders Co; 1996:1123-24.

Yamada T, et al, eds. Textbook of Gastroenterology. 2nd ed. Philadelphia, PA: J.B. Lippincott Company; 1995:959-60.

Beighton P, ed. McKusick's Heritable Disorders of Connective Tissue. 5th ed. St. Louis, MO: Mosby-Year Book, Inc; 1993:335-65.

Kelley WN, et al, eds. Textbook of Rheumatology. 4th ed. Philadelphia, PA: W.B. Saunders Company; 1993:1585.

Champion RH, et al, eds. Textbook of Dermatology. 5th ed. Cambridge, MA: Blackwell Scientific Publications; 1992:1782-87, 2666.

Buyse ML, ed. Birth Defects Encyclopedia. Dover, MA: Blackwell Scientific Publications; For: The Center for Birth Defects Information Services Inc; 1990:1425-6.

Habit, TP. Clinical Dermatology, 2nd ed. St. Louis, MO: C.V. Mosby Company; 1990: 659.

Gorlin RJ, et al, eds. Syndromes of the Head and Neck, 3rd ed. New York, NY: Oxford University Press; 1990:478-81.

Braunwald E, ed. Heart Disease. A Textbook of Cardiovascular Medicine. 3rd ed. Philadelphia, PA: W. B. Saunders Company; 1988:1728.

JOURNAL ARTICLES
Ringpfeil F, et al. Pseudoxanthoma elasticum: mutations in the MRP6 gene encoding a transmembrane ATP-binding cassette (ABC) transporter. Proc Natl Acad Sci USA. 2000;97:6001-6.

Le Saux O, et al. Mutations in a gene encoding an ABC transporter cause pseudoxanthoma elasticum. Nat Genet. 2000;25:223-7.

Bergen AA, et al. Mutations in the ABCC6 gene cause pseudoxanthoma elasticum. Nat Genet. 2000;25:228-31.

Bale SJ, et al. Recent advances in gene mapping of skin diseases. Pseudoxanthoma elasticum: a satisfying sibling study. J Cutan Med Surg. 1999;3:154-6.

Uitto J, et al. Report on the international centennial meeting on pseudoxanthoma elasticum. J Investigative Dermatology. 1998;110:840-2.

Van Soest S, et al. A locus for autosomal recessive pseudoxanthoma elasticum, with penetrance of vascular symptoms in carriers, maps to chromosome 16p13.1. Genome Research. 1997;7:830-84.

Struk B, et al. Mapping of both autosomal recessive and dominant variants of pseudoxanthoma elasticum to chromosome 16p13.1. Human Molecular Genetics. 1997;6:1823-28.

Truter S, et al. Calcification of elastic fibers in pseudoxanthoma elasticum. Mt Sinai J Med. 1996;63:210-5.

Godrey M, et al. Fibrillin immunofluorescence in pseudoxanthoma elasticum. J Am Acad Dermatol. 1995;32:589-94.

INTERNET
Online Mendelian Inheritance in Man (OMIM). The Johns Hopkins University. Pseudoxanthoma Elasticum; PXE. Entry No: 264800. Last Updated February 8, 2012.
Available at: http://www.ncbi.nlm.nih.gov/omim/. Accessed February 15, 2012.

Online Mendelian Inheritance in Man (OMIM). The Johns Hopkins University. http://omim.org/geneMap/16/154?start=-3&limit=10&highlight=154Pseudoxanthoma Elasticum, Forme Fruste. Entry No: 177850. Last Edited June 29, 2010. Available at: http://www.ncbi.nlm.nih.gov/omim/. Accessed February 15, 2012.

The information in NORD’s Rare Disease Database is for educational purposes only. It should never be used for diagnostic or treatment purposes. If you have questions regarding a medical condition, always seek the advice of your physician or other qualified health professional. NORD’s reports provide a brief overview of rare diseases. For more specific information, we encourage you to contact your personal physician or the agencies listed as “Resources” on this report.

Report last updated: 2012/03/12 00:00:00 GMT+0

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