|55 Kenosia Avenue
Danbury, CT 06810
Toll Free: 1.800.999.6673
The National Organization for Rare Disorders (NORD) web site, its databases, and the contents thereof are copyrighted by NORD. No part of the NORD web site, databases, or the contents may be copied in any way, including but not limited to the following: electronically downloading, storing in a retrieval system, or redistributing for any commercial purposes without the express written permission of NORD. Permission is hereby granted to print one hard copy of the information on an individual disease for your personal use, provided that such content is in no way modified, and the credit for the source (NORD) and NORD’s copyright notice are included on the printed copy. Any other electronic reproduction or other printed versions is strictly prohibited.
The information in NORD’s Rare Disease Database is for educational purposes only. It should never be used for diagnostic or treatment purposes. If you have questions regarding a medical condition, always seek the advice of your physician or other qualified health professional. NORD’s reports provide a brief overview of rare diseases. For more specific information, we encourage you to contact your personal physician or the agencies listed as “Resources” on this report.
Copyright 1987, 1989, 1997, 2005
Sialadenitis is a condition characterized by inflammation and enlargement of one or more of the salivary glands, the glands that secrete saliva into the mouth. There are both acute and chronic forms. Sialadenitis is often associated with pain, tenderness, redness, and gradual, localized swelling of the affected area. The exact cause of sialadenitis is not known.
Symptoms of sialadenitis include enlargement, tenderness, and redness of one or more salivary glands. These are the glands in the mouth, located near the ear (parotid), under the tongue (sublingual), and under the jaw bone (submaxillary), plus numerous small glands in the tongue, lips, cheeks and palate. Salivary stones (calculi) may block secretions from any of these glands. The gland may sometimes become infected, leading to fever and other complications.
Decreased salivary flow is a hallmark of both the acute and chronic forms of sialadenitis. The pain is more obvious while eating, and more than three-quarters of patients complain of dry mouth (xerostomia).
The exact cause of sialadenitis is unknown. In some cases, the condition may be associated with the formation of salivary gland stones (sialolithiasis).
Sialadenitis affects males and females in equal numbers. It shows no racial biases.
Mikulicz Syndrome is a benign chronic lymphocytic infiltration and enlargement of the tonsils and salivary glands near the ear (parotid gland), beneath the upper jaw bone (submaxillary), tear (lacrimal) and other glands. This condition causes excessive dryness of the mouth and eyes and is often related to Sjogren's Syndrome. (For more information on this disorder, choose "Mikulicz" as your search term in the Rare Disease Database.)
Sjogren Syndrome is a degeneration of the tear and salivary glands that may be associated with arthritis. Patients often complain of a gritty, burning sensation in their eyes due to loss of lubrication. When their mouths become dry, chewing and swallowing food is difficult. The lack of saliva causes particles of food to stick to the cheeks, gums, and throat. Other symptoms may include a weak voice, dental decay, dryness of the nose, skin and vagina. (For more information on this disorder, choose "Sjogren" as your search term in the Rare Disease Database.)
Mixed Tumor of the Salivary Gland (Pleomorphic Adenoma of the Salivary Gland) is a slowly growing, benign tumor of unknown origin. It is usually located in the parotid salivary glands. Onset of the disorder is slow, but later the tumor tends to grow rapidly. Paralysis of the facial muscles is a rare complication. Sometimes pain occurs in conjunction with the tumor. This disorder tends to be familial and can occur in multiple family members.
Periodic Sialadenosis (Periodic Sialorrhea, or Recurring Salivary Adenitis) is a disorder of unknown cause, possibly of autosomal dominant inheritance. It is characterized by sudden discomfort in the region of the salivary glands near the ear and jaws. An unusually large flow of saliva may occur. The outer ear sometimes appears distorted.
The disorder is often diagnosed by means of a thorough patient history and physical examination. Recent advances in endoscopic equipment make the diagnosis somewhat easier.
Initial treatment of sialadenitis involves antibiotic therapy and rehydration of the patient. Patients are referred to specialists (otolaryngologists) if any signs of facial nerve involvement are present or if drainage of the swelling is contemplated. If a stone is present, gentle massage may help move it out of the gland. Otherwise, surgery may be indicated.
Information on current clinical trials is posted on the Internet at www.clinicaltrials.gov. All studies receiving U.S. government funding, and some supported by private industry, are posted on this government web site.
For information about clinical trials being conducted at the NIH Clinical Center in Bethesda, MD, contact the NIH Patient Recruitment Office:
Tollfree: (800) 411-1222
TTY: (866) 411-1010
For information about clinical trials sponsored by private sources, contact:
A clinical trial on the treatment of chronic sialadenitis with intraductal penicillin or saline produced promising results. Additional study of this treatment method is needed.
Other experimental investigations deal with improved endoscopic techniques for the imaging and detection of chronic sialadenitis.
PO Box 8126
Gaithersburg, MD 20898-8126
Phone #: 301-251-4925
800 #: 888-205-2311
Home page: http://rarediseases.info.nih.gov/GARD/
PO Box 241956
Los Angeles, CA 90024
Phone #: 310-264-0826
800 #: N/A
Home page: http://www.madisonsfoundation.org
Building 31, Room 2C39
31 Center Drive, MSC 2290
Bethesda, MD 20892 USA
Phone #: 301-496-4261
800 #: 866-232-4528
Home page: http://www.nidcr.nih.gov/
Ballenger JJ, ed. Diseases of the Nose, Throat, Ear, Head and Neck. 14th ed. Lea & Febiger, Malvern, PA; 1991:300-301.
Morimoto Y, Tanaka T, Tominaga K, et al. Clinical application of magnetic resonance sialographic 3-dimensional reconstruction imaging and magnetic resonance virtual endoscopy for salivary gland duct analysis. J Oral Maxillodac Surg. 2004;62:1237-45.
Zenk J, Koch M, Bozzato A, et al. Sialoscopy- initial experiences with a new endoscope. Br J Oral Maxillofac Surg. 2004;42:293-98.
Antoniades D, Harrison JD, Epivatianos A, et al. Treatment of chronic sialadenitis by intraductal penicillin or saline. J Oral Maxillodac Surg. 2004;62:431-34.
Grotz KA, Wustenberg P, Kohnen R, et al. Prophylaxis of radiogenic sialadenitis and mucositis by coumarin/troxerutine in patients with head and neck cancer - a prospective, randomized, placebo-controlled, double-blind study. Br J Oral Maxillofac Surg. 2001;39:34-39.
FROM THE INTERNET
Sclerosing Sialadenitis. The Doctor's Doctor. Last Updated 3/27/2003. 11pp.
Yoskovitch A. Submandibular Sialadenitis/Sialadenosis. emedicine. Last Updated: November 18, 2003. 15pp.
Report last updated: 2008/04/25 00:00:00 GMT+0