You are here: Home / Rare Disease Information / Rare Disease Database

Search Rare Diseases

Enter a disease name or synonym to search NORD's database of reports.

0-9 - A - B - C - D - E - F - G - H - I - J - K - L - M - N - O - P - Q - R - S - T - U - V - W - X - Y - Z

Chronic Intestinal Pseudo-obstruction

Abstract

You are reading a NORD Rare Disease Report Abstract. NORD’s full collection of reports on over 1200 rare diseases is available to subscribers (click here for details). We are now also offering two full rare disease reports per day to visitors on our Web site.

NORD is very grateful to Edy E. Soffer, MD, Center for Digestive Diseases, GI Motility Program, Department of Gastroenterology, Cedars Sinai Medical Center, for the assistance in the preparation of this report.

Synonyms of Chronic Intestinal Pseudo-obstruction

  • chronic idiopathic intestinal pseudo-obstruction
  • CIIP
  • CIP
  • pseudo-obstruction syndrome

Disorder Subdivisions

  • No subdivisions found.

General Discussion

Summary
Chronic intestinal pseudo-obstruction (CIP) is a rare, potentially disabling gastrointestinal disorder characterized by abnormalities affecting the involuntary, coordinated muscular contractions (a process called peristalsis) of the gastrointestinal (GI) tract. Peristalsis propels food and other material through the digestive system under the control of nerves, pacemaker cells and hormones. CIP usually results from abnormalities affecting the muscles or nerves that are involved in peristalsis. Consequently, peristalsis becomes altered and inefficient. The symptoms of CIP resemble those caused by mechanical obstruction of the small bowel. Mechanical obstruction refers to something (such as a tumor, scar tissue, etc.) physically blocking the passage of food and other material through the GI tract. In individuals with CIP no such physical obstruction is present, hence the term pseudo-obstruction. Common symptoms include nausea, vomiting, abdominal pain, abdominal swelling (distention) and constipation. Ultimately, normal nutritional requirements cannot be met leading to unintended weight loss and malnourishment. CIP can potentially cause severe, even life-threatening complications.

Introduction
There is no agreed upon classification system for CIP and proposed classification systems tend to be complex and confusing. There are also many different causes of CIP, which only adds to the confusion. The unifying concept for CIP regardless of cause is an abnormality affecting the passage of food and other material through the digestive system (gastrointestinal motility). Generally, CIP is broken down into two main forms depending on whether the disorder involves the muscles (myopathic CIP) or nerves (neuropathic CIP) of the GI tract that are involved in peristalsis. Some researchers lump enteric dysmotility together with CIP. The prognosis of this separate yet similar condition is different from CIP. This report deals solely with the strict definition of CIP as a disorder that causes an "obstruction-like" picture.

Chronic Intestinal Pseudo-obstruction Resources

NORD Member Organizations:

(To become a member of NORD, an organization must meet established criteria and be approved by the NORD Board of Directors. If you're interested in becoming a member, please contact Susan Olivo, Membership Manager, at solivo@rarediseases.org.)

Other Organizations:

The information in NORD’s Rare Disease Database is for educational purposes only. It should never be used for diagnostic or treatment purposes. If you have questions regarding a medical condition, always seek the advice of your physician or other qualified health professional. NORD’s reports provide a brief overview of rare diseases. For more specific information, we encourage you to contact your personal physician or the agencies listed as “Resources” on this report.

0-9 - A - B - C - D - E - F - G - H - I - J - K - L - M - N - O - P - Q - R - S - T - U - V - W - X - Y - Z

NORD's Rare Disease Information Database is copyrighted and may not be published without the written consent of NORD.

 
Copyright ©2014 NORD - National Organization for Rare Disorders, Inc. All rights reserved.
The following trademarks/registered service marks are owned by NORD: NORD, National Organization for Rare Disorders, the NORD logo, RareConnect. .