You are reading a NORD Rare Disease Report Abstract. NORD’s full collection of reports on over 1200 rare diseases is available to subscribers (click here for details). We are now also offering two full rare disease reports per day to visitors on our Web site.
NORD is very grateful to D. Joanne Lynn, MD, The Ohio State University, Charles Levy, MD, North Florida/South Georgia Veterans Health Service, Adam Kaplin, MD, PhD, Johns Hopkins University School of Medicine, Benjamin Greenberg, MD, University of Texas Southwestern Medical Center, Carlos Pardo, MD Johns Hopkins University of School of Medicine and Douglas Kerr, MD, PhD, Biogen-Idec for assistance in the preparation of this report. This report was adapted from an article from The Transverse Myelitis Association and Drs. Lynn, Levy, Kaplin, Greenberg, Pardo and Kerr serve on their Medical and Scientific Council.
Synonyms of Transverse Myelitis
- No synonyms found.
- Ascending Myelitis
- Brown-Sequard Syndrome
- Concussion Myelitis
- Foix-Alajouanine Myelitis
- Funicular Myelitis
- Subacute Necrotizing Myelitis
- Systemic Myelitis
Transverse myelitis (TM) is a rare inflammatory disease causing injury to the spinal cord with varying degrees of weakness, sensory alterations, and autonomic dysfunction (the part of the nervous system that controls involuntary activity, such as the heart, breathing, the digestive system, and reflexes).
The first cases of acute myelitis were described in 1882 and were attributed to vascular lesions and acute inflammatory events. In England between 1922 and 1923 more than 200 postvaccinial cases were noted as complications of the smallpox and rabies vaccines. Later reports revealed that TM was post-infectious in nature, and agents including measles, rubella and mycoplasma were directly isolated from patient’s spinal fluid. The term "acute transverse myelitis" was first used by an English neurologist in 1948 to describe a case of rapidly progressive paraparesis with a thoracic sensory level, occurring as a postinfectious complication of pneumonia. The Transverse Myelitis Consortium Working Group delineated diagnostic criteria for disease-associated TM and idiopathic TM along with a framework to differentiate TM from non-inflammatory myelopathies in 2002.
Organizations related to Transverse Myelitis
The information in NORD’s Rare Disease Database is for educational purposes only. It should never be used for diagnostic or treatment purposes. If you have questions regarding a medical condition, always seek the advice of your physician or other qualified health professional. NORD’s reports provide a brief overview of rare diseases. For more specific information, we encourage you to contact your personal physician or the agencies listed as “Resources” on this report.
The National Organization for Rare Disorders (NORD) web site, its databases, and the contents thereof are copyrighted by NORD. No part of the NORD web site, databases, or the contents may be copied in any way, including but not limited to the following: electronically downloading, storing in a retrieval system, or redistributing for any commercial purposes without the express written permission of NORD. Permission is hereby granted to print one hard copy of the information on an individual disease for your personal use, provided that such content is in no way modified, and the credit for the source (NORD) and NORD’s copyright notice are included on the printed copy. Any other electronic reproduction or other printed versions is strictly prohibited.
Copyright 1988, 1989, 1996, 2004, 2012
NORD's Rare Disease Information Database is copyrighted and may not be published without the written consent of NORD.