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Tooth and Nail Syndrome

Abstract

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Synonyms of Tooth and Nail Syndrome

  • Dysplasia of Nails With Hypodontia
  • Nail Dysgenesis and Hypodontia

Disorder Subdivisions

  • No subdivisions found.

General Discussion

Tooth and nail syndrome is a rare genetic disorder that belongs to a group of diseases known as ectodermal dysplasia, which group consists of more than 100 separate recognized syndromes. Ectodermal dysplasias typically affect the teeth, nails, hair, and/or skin. Tooth and nail syndrome is characterized by absence (hypodontia) and/or malformation of certain primary (deciduous) and secondary (permanent) teeth occurring in association with improper development (dysplasia) of the nails, particularly the toenails.

In individuals with Tooth and nail syndrome, certain primary teeth and/or several secondary teeth may either be absent or widely spaced and/or conical in shape (coniform). In addition, the nails in young children with the disorder, especially the toenails, may be unusually small and underdeveloped (hypoplastic), with distinctive, abnormal hollowing causing them to appear to be spoon-shaped. Tooth and nail syndrome is inherited as an autosomal dominant genetic trait.

Organizations related to Tooth and Nail Syndrome

(Please note that some of these organizations may provide information concerning certain conditions potentially associated with this disorder [e.g., dental abnormalities, etc.].)

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