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Primary Lateral Sclerosis

Abstract

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Synonyms of Primary Lateral Sclerosis

  • Central Motor Neuron Disease
  • PLS

Disorder Subdivisions

  • No subdivisions found.

General Discussion

Primary lateral sclerosis (PLS) is a rare, neuromuscular disorder that affects the central motor neurons and is characterized by painless but progressive weakness and stiffness of the muscles of the legs. Such weakness may progress to affect the arms and the muscles at the base of the brain (bulbar muscles). Less frequently, the muscles of the face are affected. In most cases, the disorder affects adults during midlife. The exact cause of primary lateral sclerosis is unknown.

Organizations related to Primary Lateral Sclerosis

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