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Melnick Needles Syndrome

Abstract

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NORD is very grateful to Jeffrey A. Wong, MD, FACC, Division of Pediatrics, Cedars-Sinai Medical Center and The Heart Center, Children's Hospital of Los Angeles, for assistance in the preparation of this report.

Synonyms of Melnick Needles Syndrome

Melnick-Needles osteodysplasty
MNS
osteodysplasty of Melnick and Needles

Disorder Subdivisions

No subdivisions found.

General Discussion

Melnick-Needles syndrome (MNS) is a genetic disorder of bone characterized by skeletal abnormalities and a specific facial appearance. The skeletal abnormalities include bowing of long bones, s-curved leg bones, ribbon-like ribs and a hardening of the skull base. The typical facial features include prominent, protruding eyes, full cheeks, an extremely small lower jaw and a hairy forehead. The condition may affect many bones of the body causing deformity and in some cases short stature. MNS is thought to be inherited as an X-linked dominant genetic disorder.

Organizations related to Melnick Needles Syndrome

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