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Mucous Membrane Pemphigoid

Abstract

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NORD is very grateful to Carl M. Allen, DDS, MSD, Professor and Chair, Division of Oral and Maxillofacial Pathology and Radiology, The Ohio State University College of Dentistry, for assistance in the preparation of this report.

Synonyms of Mucous Membrane Pemphigoid

  • cicatricial pemphigoid
  • CP
  • MMP
  • mucous membrane pemphigoid

Disorder Subdivisions

  • Brunsting-Perry syndrome
  • localized cicatricial pemphigoid
  • vegetating cicatricial pemphigoid

General Discussion

Mucous membrane pemphigoid (MMP) is a group of rare chronic autoimmune disorders characterized by blistering lesions that primarily affect the various mucous membranes of the body. The mucous membranes of the mouth and eyes are most often affected. The mucous membranes of the nose, throat, genitalia, and anus may also be affected. The symptoms of MMP vary among affected individuals depending upon the specific site(s) involved and the progression of the disease. Blistering lesions eventually heal, sometimes with scarring. Progressive scarring may potentially lead to serious complications affecting the eyes and throat. In some cases, blistering lesions also form on the skin, especially in the head and neck area. The exact cause of MMP is unknown.

MMP has been known by many different names within the medical literature including benign mucous membrane pemphigoid, cicatricial (scarring) pemphigoid, and ocular cicatricial pemphigoid. In March of 2002, a consensus group of researchers determined that mucous membrane pemphigoid was the best designation for this group of disorders. The term "benign" mucous membrane pemphigoid was deemed inappropriate because of the potential for serious complications in some cases. The term "cicatricial" pemphigoid excluded affected individuals who do not develop scarring. Site-specific terms such as "ocular" cicatricial pemphigoid excluded individuals with multiple site involvement.

Organizations related to Mucous Membrane Pemphigoid

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