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NORD is very grateful to Deborah Marsden, MD, Metabolism Program, Children's Hospital Boston, for assistance in the preparation of this report.
Synonyms of Mucopolysaccharidoses
- MPS Disorder
- MPS 1 H/S (Hurler/Scheie Syndrome)
- MPS I H (Hurler Disease)
- MPS II-(Hunter Syndrome)
- MPS III A, B, C, and D (Sanfillipo Syndrome)
- MPS I S (Scheie Syndrome)
- MPS IV A and B (Morquio Syndrome)
- MPS IX (Hyaluronidase Deficiency)
- MPS VII (Sly Syndrome)
- MPS VI (Maroteaux-Lamy Syndrome)
The mucopolysaccharidoses (MPS) are a group of inherited lysosomal storage disorders. Lysosomes function as the primary digestive units within cells. Enzymes within lysosomes break down or digest particular nutrients, such as certain carbohydrates and fats. In individuals with MPS disorders, deficiency or malfunction of specific lysosomal enzymes leads to an abnormal accumulation of certain complex carbohydrates (mucopolysaccharides or glycosaminoglycans) in the arteries, skeleton, eyes, joints, ears, skin, and/or teeth. These accumulations may also be found in the respiratory system, liver, spleen, central nervous system, blood, and bone marrow. This accumulation eventually causes progressive damage to cells, tissues, and various organ systems of the body. There are several different types and subtypes of mucopolysaccharidosis. These disorders, with one exception, are inherited as autosomal recessive traits.
Organizations related to Mucopolysaccharidoses
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