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Robinow Syndrome

Synonyms of Robinow Syndrome

  • Acral Dysostosis with Facial and Genital Abnormalities
  • Costovertebral segmentation defect with mesomelia (formerly)
  • Fetal Face Syndrome
  • Robinow Dwarfism

Disorder Subdivisions

  • Robinow Syndrome Dominant Form
  • Robinow Syndrome Recessive Form (COVESDEM Syndrome)

General Discussion

Robinow syndrome is an extremely rare inherited disorder characterized by mild to moderate short stature due to growth delays after birth (postnatal growth retardation); distinctive abnormalities of the head and facial (craniofacial) area; additional skeletal malformations; and/or genital abnormalities. The facial features of infants with Robinow syndrome resemble those of an eight-week-old fetus; within the medical literature, this condition is often referred to as "fetal face." Characteristic craniofacial features may include an abnormally large head (macrocephaly) with a bulging forehead (frontal bossing); widely spaced eyes (ocular hypertelorism) that are abnormally prominent; a small, upturned nose with nostrils that are flared forward (anteverted); and/or a sunken (depressed) nasal bridge. Skeletal malformations may include forearm bones (radius and ulna) that are unusually short (forearm brachymelia), abnormally short fingers and toes, permanent fixation of the fifth fingers in a bent position (clinodactyly), unusually small hands with broad thumbs, malformation of the ribs, abnormal side-to-side curvature of the spine (scoliosis), and/or underdevelopment of one side of the bones in the middle (thoracic) portion of the spinal column (hemivertebrae). Genital abnormalities associated with Robinow syndrome may include an abnormally small penis (micropenis) and failure of the testes to descend into the scrotum (cryptorchidism) in affected males and underdevelopment (hypoplasia) of the clitoris and the outer, elongated folds of skin on either side of the vaginal opening (labia majora) in affected females. The range and severity of symptoms vary from case to case.

In some cases, Robinow syndrome has autosomal dominant inheritance; in other cases, the disorder may have an autosomal recessive mode of inheritance. According to the medical literature, individuals with the recessive form of Robinow syndrome may have more numerous abnormalities of the ribs and the bones of the spinal column (vertebrae) than in the dominant form of the disorder. In addition, the symptoms and physical findings associated with the recessive form tend to be more severe.

Symptoms

Robinow syndrome is an extremely rare inherited disorder characterized by short stature; characteristic facial features; skeletal malformations; and/or genital abnormalities. The range and severity of symptoms associated with Robinow syndrome vary from case to case.

In most cases, infants with Robinow syndrome experience growth delays (i.e., growth retardation and delayed bone age) after birth (postnatally). Growth delays continue during childhood, resulting in slight to moderate short stature. In rare cases, individuals with the dominant form of Robinow syndrome may reach normal adult height. In approximately 20 percent of cases, affected children may exhibit mental retardation, delays in reaching developmental milestones, and/or delays in developing language skills.

In most infants with Robinow syndrome, the facial features resemble those of an eight-week-old fetus, a condition often termed "fetal face" within the medical literature. Characteristic abnormalities of the head and facial (craniofacial) area may include an abnormally large head (macrocephaly) with a bulging forehead (frontal bossing) and underdevelopment of the middle portion of the face (midface hypoplasia). Affected infants may also have widely spaced eyes (ocular hypertelorism) that are abnormally prominent; unusually wide, downwardly slanting eyelid folds (palpebral fissures); a small, upturned nose with nostrils that are flared forward (anteverted); a sunken (depressed) nasal bridge; and/or abnormally positioned (i.e., posteriorly rotated) ears. In addition, in some cases, affected infants may have an abnormally broad, triangularly-shaped downwardly turned mouth with an abnormally long groove (philtrum) in the center of the upper lip; a small chin; an unusually small jaw (micrognathia); and/or abnormally overgrown gums (gingival hyperplasia). Dental abnormalities may also be present including misaligned teeth, crowding of the back (posterior) teeth, and/or delayed eruption of the secondary (permanent) teeth. In some cases, a certain soft-tissue structure at the back of the throat (uvula) may be underdeveloped or abnormally divided (bifid). In addition, affected infants may also have incomplete closure of the roof of the mouth (cleft palate), an abnormal vertical groove in the upper lip, and/or restricted movements of the tongue (ankyloglossia). In some affected infants and children, ankyloglossia may contribute to delays in language skill development. In most cases, the facial abnormalities associated with Robinow syndrome become less pronounced as affected children age.

In many cases, infants with Robinow syndrome may also have skeletal abnormalities including forearm bones (radius and ulna) that are abnormally short and underdeveloped (forearm brachymelia); abnormal deviation of the thumb side of the forearm (radius) due to shortening of the radius (Madelung deformity of the wrist); unusually short fingers (brachydactyly); permanent fixation of the fifth fingers in a bent position (clinodactyly); and/or abnormally small hands with broad thumbs. In some cases, the end bones (terminal phalanges) of the thumbs and great toes may be abnormally divided (bifid) and/or the bones (phalanges) of the fingers and toes may be underdeveloped (hypoplastic). Additional abnormalities may include dislocation of the hips, limited extension of the elbows, abnormal fusion or absence of certain ribs, abnormal side-to-side curvature of the spine (scoliosis), underdevelopment of one side of the bones (vertebrae) in the middle (thoracic) portion of the spinal column (hemivertebrae), and/or fusion of certain vertebrae. In addition, affected infants may exhibit abnormal depression of the bone forming the center of the chest ("funnel chest" or pectus excavatum). In some cases, infants with Robinow syndrome may also have malformed (dysplastic) nails and/or abnormalities of the skin ridge patterns (dermatoglyphics) on the fingers and palms.

In most cases, infants with Robinow syndrome also have abnormalities of the genitals. In some cases, affected infants may have external genitals that are not distinctly male or female (ambiguous genitalia). However, in such cases, gender can be properly determined during early infancy. In females, the clitoris and the outer, elongated folds of skin on either side of the vaginal opening (labia majora) may be underdeveloped (hypoplastic). In males, the penis may be abnormally small (micropenis) and may be hidden under the surrounding skin; in addition, one or both of the testes may fail to descend into the scrotum (cryptorchidism). In rare cases, affected males may have abnormally low levels of testicular function (partial primary hypogonadism); however, in such cases, affected males experience normal development of secondary sexual characteristics (e.g., deepening of the voice, characteristic hair growth patterns, sudden increase in growth and development of the testes and scrotum, etc.) with the exception of the persistence of micropenis. According to the medical literature, sexual function is possible in many affected males, and male reproduction has been reported repeatedly in those with the dominant form of the disorder. However, reproduction in males with the recessive form of Robinow syndrome has not yet been reported. In most cases, affected females exhibit normal function of the ovaries (normal gonadal function) and normal fertility.

In some cases, individuals with Robinow syndrome may have additional physical abnormalities such as duplication of the kidneys, unusual accumulation of urine in the kidney (hydronephrosis), protrusion of portions of the large intestine through an abnormal opening in the muscular lining of the abdominal cavity (inguinal hernia), and/or protrusion of portions of the large intestine through the abdominal wall near the navel (umbilical hernia). In addition, approximately 13 percent of infants with Robinow syndrome have heart (cardiac) defects that are present at birth (congenital heart defects). In such cases, the most common heart defect has been "right ventricular outlet obstruction," in which the flow of blood from the lower chamber of the heart (ventricle) was obstructed due to abnormal narrowing (stenosis) or closure (atresia) of the vessel that arises from the ventricle (pulmonary trunk) and divides into the left and right pulmonary arteries. Symptoms associated with this heart defect vary greatly depending upon the size and location of the obstruction. In some infants with Robinow syndrome, other cardiac abnormalities may be present including complex congenital heart defects that may lead to life-threatening complications. In addition, in rare cases, infants and children with Robinow syndrome may be prone to repeated infections of the lungs (pneumonia). In rare, severe cases, without appropriate treatment, pneumonia may result in life-threatening complications.

The dominant and recessive forms of Robinow syndrome share many of the same symptoms and physical findings (e.g., craniofacial abnormalities, short stature, skeletal malformations, and genital hypoplasia). However, in most cases, the symptoms and physical findings associated with the recessive form tend to be more severe. Researchers suggest that, infants with the recessive form of Robinow syndrome exhibit more numerous rib abnormalities (e.g., abnormal displacement, fusion, and/or absence of certain ribs) and defects affecting bones of the spinal column (vertebrae) than those infants with the dominant form of the disorder. In addition, short stature, underdevelopment of the forearm bones (radioulnar hypoplasia), and abnormalities of the fingers are more severe. In most cases, affected individuals exhibit dislocation of the head of one of the forearm bones (radial head dislocation), an abnormality rarely seen in individuals with the dominant form of Robinow syndrome. Individuals with the recessive form may also tend to have a more triangularly-shaped mouth.

Causes

Robinow syndrome may have autosomal dominant or recessive inheritance. The medical literature is unclear as to which inheritance pattern tends to occur more often. In approximately 20 percent of cases, classification into recessive and dominant forms cannot be determined.

Genetic diseases are determined by two genes, one received from the father and one from the mother. Dominant genetic disorders occur when only a single copy of an abnormal gene is necessary for the appearance of the disease. The abnormal gene can be inherited from either parent, or can be the result of a new mutation (gene change) in the affected individual. The risk of passing the abnormal gene from affected parent to offspring is 50% for each pregnancy regardless of the sex of the resulting child.

Recessive genetic disorders occur when an individual inherits the same abnormal gene for the same trait from each parent. If an individual receives one normal gene and one gene for the disease, the person will be a carrier for the disease, but usually will not show symptoms. The risk for two carrier parents to both pass the defective gene and, therefore, have an affected child is 25% with each pregnancy. The risk to have a child who is a carrier like the parents is 50% with each pregnancy. The chance for a child to receive normal genes from both parents and be genetically normal for that particular trait is 25%.

Some cases of Robinow syndrome have had parents who were related by blood (consanguineous). All individuals carry 4-5 abnormal genes. Parents who are close relatives (consanguineous) have a higher chance than unrelated parents to both carry the same abnormal gene, which increases the risk to have children with a recessive genetic disorder.

Investigators have determined that autosomal recessive Robinow syndrome occurs due to disruption or changes (mutations) in the ROR2 gene located on chromosome 9 (9q22). Chromosomes, which are present in the nucleus of human cells, carry the genetic information for each individual. Pairs of human chromosomes are numbered from 1 through 22, and an additional 23rd pair of sex chromosomes which include one X and one Y chromosome in males and two X chromosomes in females. Each chromosome has a short arm designated "p" and a long arm designated "q". Chromosomes are further sub-divided into many bands that are numbered. For example, "chromosome 9q22" refers to band 22 on the long arm of chromosome 9. The numbered bands specify the location of the thousands of genes that are present on each chromosome.

Affected Populations

Robinow syndrome is thought to affect males and females in equal numbers. However, affected males may be diagnosed and reported more frequently due to the presence of distinct genital abnormalities (e.g., micropenis) associated with the disorder. According to the medical literature, there is approximately one case of Robinow syndrome in every 500,000 births or about six new cases recognized per year in the United States. More than 100 cases have been reported in the medical literature since M. Robinow originally described the disorder in 1969. The autosomal recessive form of Robinow syndrome occurs with greater frequency in Turkey. In most cases, the physical abnormalities associated with Robinow syndrome are apparent at birth (congenital).

Related Disorders

Symptoms of the following disorders may be similar to those of Robinow syndrome. Comparisons may be useful for a differential diagnosis:

Achondroplasia is an inherited disorder characterized by abnormally short arms and legs and short stature (short-limbed dwarfism), abnormal facial features, and/or skeletal malformations. Characteristic facial features may include an abnormally large head (macrocephaly), unusual prominence of the forehead (frontal bossing), a low nasal bridge, and/or underdevelopment of the middle portion of the face (midface hypoplasia). Skeletal malformations may include unusually short fingers and toes (brachydactyly), abnormally increased backward curvature of the spine (lordosis), legs that bow outward (genu varum), and/or narrowing (stenosis) of the spine. Additional abnormalities may include limited extension of the elbows and hips, diminished muscle tone (hypotonia), and/or frequent infections of the middle ear (otitis media). In most cases, achondroplasia appears to occur randomly, for no apparent reason (sporadic). (For more information on this disorder, choose "Achondroplasia" as your search term in the Rare Disease Database.)

Aarskog syndrome is a very rare inherited disorder characterized by abnormalities of the head and facial (craniofacial) area, slight to moderate short stature, malformations of the skeleton, and/or abnormalities of the genitals. Characteristic facial features may include widely spaced eyes (ocular hypertelorism), downwardly slanting eyelid folds (palpebral fissures), a small nose with nostrils that are flared forward (anteverted nares), and/or underdevelopment of the upper jaw (maxillary hypoplasia). Skeletal malformations may include abnormally short fingers (brachydactyly), permanent fixation of the fifth fingers in a bent position (clinodactyly), and/or unusually broad thumbs and great toes. Genital abnormalities may include an abnormal fold of skin extending around the base of the penis (shawl scrotum) and/or failure of one or both of the testes to descend into the scrotum (cryptorchidism). In addition, approximately one third of children with Aarskog syndrome exhibit mild to moderate mental retardation. Aarskog syndrome is thought to be inherited as a X-linked genetic trait. (For more information on this disorder, choose "Aarskog" as your search term in the Rare Disease Database.)

Albright hereditary osteodystrophy is a rare disorder characterized by short stature, an unusually round face, abnormally short fingers (brachydactyly), and/or the development of bony growths (osseous plaques) on the surface of the skin. These growths may spread to affect lower layers of the skin tissue (subcutaneous ossification). The abnormal development of bone in Albright hereditary osteodystrophy is limited to the skin (i.e., it does not involve the connective tissue, muscle, etc.). Other features associated with the disorder may include obesity, mild mental retardation, abnormally low levels of calcium in the blood (hypocalcemia), and/or the clinical features of pseudohypoparathyroidism (e.g., weakness, muscle cramps, excessive nervousness, headaches, and/or abnormal sensations such as tingling, burning, and numbness of the hands). When infants with Albright hereditary osteodystrophy have severe abnormalities affecting the facial area and extremities, they may resemble infants with Robinow syndrome. Albright hereditary osteodystrophy is thought to be inherited as an autosomal dominant genetic disorder.

Omodysplasia is a rare inherited bone disorder that may be characterized by abnormal shortness of certain long bones of the arms (i.e., humeri) and legs (i.e., thigh bone or femora), short stature, and characteristic facial features including a depressed nasal bridge, broad base of the nose, and/or an unusually long vertical groove (philtrum) in the center of the upper lip. In addition, affected individuals may demonstrate abnormal separation of the two bones of the forearms (radioulnar diastasis), dislocation of the head of the radius, and/or underdevelopment (hypoplasia) of the rounded mass of bone (condyle) at the end of the humerus. Omodysplasia may be inherited as either an autosomal recessive or autosomal dominant genetic disorder.

Standard Therapies

Diagnosis
In some cases, Robinow syndrome may be detected before birth (prenatally) based upon specialized testing (ultrasonography). During fetal ultrasonography, reflected sound waves create an image of the developing fetus, potentially revealing characteristic findings suggestive of Robinow syndrome.

A diagnosis of Robinow syndrome may be confirmed after birth (postnatally) based upon a thorough clinical evaluation, identification of characteristic physical features (e.g., craniofacial, digital, forearm, genital, and/or other malformations), and advanced imaging techniques. Specialized x-ray studies may confirm the presence and/or extent of certain observed craniofacial and skeletal abnormalities. For example, such imaging tests may confirm abnormal smallness of the jaw (micrognathia) and underdevelopment of bones of the fingers and/or forearms. In addition, x-ray studies may reveal abnormalities of the vertebrae and rib cage. In rare cases, after puberty in some affected males, blood tests may reveal the presence of elevated levels of follicle-stimulating hormone (FSH), suggesting partial primary hypogonadism.

Because the autosomal recessive form of Robinow syndrome has been linked to mutations of the ROR2 gene, gene analysis may become available to confirm a diagnosis in the future.

Treatment
The treatment of Robinow syndrome is directed toward the specific symptoms that are apparent in each individual. Treatment may require the coordinated efforts of a team of specialists. Pediatricians, specialists who treat skeletal abnormalities (orthopedists), surgeons, specialists who diagnose and treat heart problems (cardiologists), physical therapists, and/or other health care professionals may need to systematically and comprehensively plan an affected child's treatment.

In affected infants who have ambiguous genitalia, gender may be properly determined by clinical examination during the newborn period. In some cases, surgery may be performed and/or other measures may be taken to correct cryptorchidism and/or other genital abnormalities.

In some cases, braces, casts, special exercises, and/or surgery may be beneficial in treating certain vertebral abnormalities. In some cases, surgery may also be performed to correct inguinal hernias, certain craniofacial abnormalities, and/or other malformations. Use of braces, dental surgery, and/or other supportive techniques may be used to help correct misalignment of the teeth and/or other dental abnormalities.

In addition, infants and children with Robinow syndrome should receive thorough medical evaluations to ensure prompt detection and immediate appropriate treatment of heart (cardiac) abnormalities that may be potentially associated with the disorder. Affected infants and children should also be carefully monitored to help prevent and/or immediately detect infections of the lungs (pneumonia) and to ensure prompt, appropriate treatment.

Early intervention is important to ensure that children with Robinow syndrome reach their potential. Special services that may be beneficial to affected children may include special remedial education, special social support, physical therapy, and/or other medical, social, and/or vocational services.

Genetic counseling will be of benefit for affected individuals and their families. Other treatment for this disorder is symptomatic and supportive.

Investigational Therapies

Information on current clinical trials is posted on the Internet at www.clinicaltrials.gov. All studies receiving U.S. government funding, and some supported by private industry, are posted on this government web site.

For information about clinical trials being conducted at the NIH Clinical Center in Bethesda, MD, contact the NIH Patient Recruitment Office:

Tollfree: (800) 411-1222
TTY: (866) 411-1010
Email: prpl@cc.nih.gov

For information about clinical trials sponsored by private sources, contact:
www.centerwatch.com

Robinow Syndrome Resources

(Please note that some of these organizations may provide information concerning certain conditions potentially associated with this disorder [e.g., short stature, mental retardation, etc.].)

NORD Member Organizations:

(To become a member of NORD, an organization must meet established criteria and be approved by the NORD Board of Directors. If you're interested in becoming a member, please contact Susan Olivo, Membership Manager, at solivo@rarediseases.org.)

Other Organizations:

References

TEXTBOOKS
Patton MA, Afzal AR. Robinow Syndrome. In: NORD Guide to Rare Disorders. Lippincott Williams & Wilkins. Philadelphia, PA. 2003:725-6.

Jones KL., ed. Smith's Recognizable Patterns of Human Malformation. 5th ed. Philadelphia, PA: W. B. Saunders Co: 1997:128-30.

Gorlin RJ, et al., eds. Syndromes of the Head and Neck, 3rd ed. New York, NY: Oxford University Press; 1990:796-97.

Buyce ML., ed. Birth Defects Encyclopedia. Dover, MA: Blackwell Scientific Publications; For: The Center for Birth Defects Information Services Inc; 1990:1499-1500.

JOURNAL ARTICLES
Afzal AR, Jeffery S. One gene, two phenotypes: ROR2 mutations in autosomal recessive Robinow syndrome and autosomal dominant brachydactyly type B. Hum Mutat. 2003;22:1-11.

Patton MA, Afzal AR. Robinow syndrome. J Med Genet. 2002;39:305-10.

Venditti CP, et al. Omodysplasia: an affected mother and son. Am J Med Genet. 2002;111:169-77.

Van Bokhoven H, et al. Mutation of the gene encoding the ROR2 tyrosine kinase causes autosomal recessive Robinow syndrome. Nat Genet. 2000;25:423-6.

Turnpenny PD, et al. Dwarfism, rhizomelic limb shortness, and abnormal face: new short stature syndrome sharing some manifestations with Robinow syndrome. Am J Med Genet. 1992;42:724-7.

Webber SA, et al. Congenital heart disease and Robinow syndrome: coincidence or an additional component of the syndrome? Am J Med Genet 1990;37:519-21.

Teebi AS. Autosomal recessive Robinow syndrome. Am J Med Genet 1990;35:64-8.

Butler MG, et al. Metacarpophalangeal pattern profile analysis in Robinow syndrome. Am J Med Genet 1987;27:219-23.

Turken A, et al. A large inguinal hernia with undescended testes and micropenis in Robinow syndrome. Clin Dysmorphol. 1996;5:175-8.

Atalay S, et al. Congenital heart disease and Robinow syndrome. Clin Dysmorphol. 1993;2:208-10.

Balci S, et al. Robinow syndrome: with special emphasis on dermatoglyphics and hand malformations (split hand). Clin Dysmorphol. 1993;2:199-207.

Robinow M. The Robinow (fetal face) syndrome: a continuing puzzle. Clin Dysmorphol. 1993;2:189-98.

Butler MG, et al. Robinow syndrome: report of two patients and review of literature. Clin Genet. 1987;31:77-85.

Schorderet DF, et al. Robinow syndrome in two siblings from consanguineous parents. Eur J Pediatr. 1992;151:586-9.

Lorenzetti MH, et al. Inverted nipples in Robinow syndrome. Genet Couns. 1996;7:67-9.

Israel H, et al. Craniofacial pattern similarities and additional orofacial findings in siblings with the Robinow syndrome. J Craniofac Genet Dev Biol. 1988;8:63-73.

Loverro G, et al. Robinow's syndrome: prenatal diagnosis. Prenat Diagn. 1990;10:121-6.

Robinow M, et al. A newly recognized dwarfing syndrome. Am J Dis Child. 1969;117:645-51.

FROM THE INTERNET
McKusick, VA. Online Mendelian Inheritance In Man (OMIM). Johns Hopkins University, Last Edit Date 7/26/96, Entry Number 180700; Last Edit Date 3/12/94, Entry Number 268310; Last Edit Date 4/4/97, Entry Number 100800; Last Edit Date 9/10/96; Entry Number 164745.

The information in NORD’s Rare Disease Database is for educational purposes only. It should never be used for diagnostic or treatment purposes. If you have questions regarding a medical condition, always seek the advice of your physician or other qualified health professional. NORD’s reports provide a brief overview of rare diseases. For more specific information, we encourage you to contact your personal physician or the agencies listed as “Resources” on this report.

Report last updated: 2007/07/23 00:00:00 GMT+0

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