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Osteonecrosis

Abstract

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NORD is very grateful to John H. Klippel, MD, President and CEO, Arthritis Foundation, for assistance in the preparation of this report.

Synonyms of Osteonecrosis

Aseptic Necrosis
Avascular Necrosis of Bone
Ischemic Necrosis of Bone

Disorder Subdivisions

No subdivisions found.

General Discussion

Osteonecrosis, also known as avascular necrosis, is a disease resulting from the temporary or permanent loss of the blood supply to the bones. Without blood, the bone tissue dies and causes the bone to collapse. If the process involves the bones near a joint, it often leads to collapse of the joint surface. This disease also is known, aseptic necrosis, and ischemic bone necrosis.

Although it can happen in any bone, osteonecrosis most commonly affects the ends (epiphysis) of long bones such as the femur, the bone extending from the knee joint to the hip joint. Other common sites include the upper arm bone, knees, shoulders, and ankles. The disease may affect just one bone, more than one bone at the same time, or more than one bone at different times. Orthopaedic doctors most often diagnose the disease.

The amount of disability that results from osteonecrosis depends on what part of the bone is affected, how large an area is involved, and how effectively the bone rebuilds itself. The process of bone rebuilding takes place after an injury as well as during normal growth. Normally, bone continuously breaks down and rebuilds--old bone is reabsorbed and replaced with new bone. The process keeps the skeleton strong and helps it to maintain a balance of minerals. In the course of osteonecrosis, however, the healing process is usually ineffective and the bone tissues break down faster than the body can repair them. If left untreated, the disease progresses, the bone collapses, and the joint surface breaks down, leading to pain and arthritis.

Organizations related to Osteonecrosis

American Academy of Orthopaedic Surgeons
- 6300 North River Road
- Rosemont, IL 60018-4262
- Phone #: 847-823-7186
- 800 #: --
- e-mail: custserv@aaos.org
- Home page: http://www.aaos.org/
Arthritis Foundation
- 1330 West Peachtree Street, Suite 100
- Atlanta, GA 30309 USA
- Phone #: 404-872-7100
- 800 #: 800-283-7800
- e-mail: arthritisfoundation@arthritis.org
- Home page: http://www.arthritis.org
Genetic and Rare Diseases (GARD) Information Center
- PO Box 8126
- Gaithersburg, MD 20898-8126
- Phone #: 301-251-4925
- 800 #: 888-205-2311
- e-mail: N/A
- Home page: http://rarediseases.info.nih.gov/GARD/
MUMS National Parent-to-Parent Network
- 150 Custer Court
- Green Bay, WI 54301-1243 USA
- Phone #: N/A
- 800 #: N/A
- e-mail: mums@netnet.net
- Home page: http://www.netnet.net/mums/
National Osteonecrosis Foundation
- Good Samaritan Professional Building
- 5601 Loch Raven Blvd., Suite 201
- Baltimore, MD 21239 USA
- Phone #: 410-532-5985
- 800 #: --
- e-mail: N/A
- Home page: http://www.nonf.org
NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases
- Information Clearinghouse
- One AMS Circle
- Bethesda, MD 20892-3675 USA
- Phone #: 301-495-4484
- 800 #: 877-226-4267
- e-mail: NIAMSinfo@mail.nih.gov
- Home page: http://www.niams.nih.gov/
NIH/Osteoporosis and Related Bone Diseases National Resource Center
- 2 AMS Circle
- Bethesda, MD 20892-3676 USA
- Phone #: 301-495-4484
- 800 #: 877-226-4267
- e-mail: NIHBoneInfo@mail.nih.gov
- Home page: http://www.bones.nih.gov

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