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Apraxia

Synonyms of Apraxia

  • No synonyms found.

Disorder Subdivisions

  • Apraxia, Buccofacial
  • Apraxia, Classic
  • Apraxia, Constructional
  • Apraxia, Ideational
  • Apraxia, Ideokinetic
  • Apraxia, Ideomotor
  • Apraxia, Motor
  • Apraxia, Oculomotor

General Discussion

Apraxia is a neurological disorder characterized by the inability to perform learned (familiar) movements on command, even though the command is understood and there is a willingness to perform the movement. Both the desire and the capacity to move are present but the person simply cannot execute the act.

Patients with apraxia cannot use tools or perform such acts as tying shoelaces or button shirts etc. The requirements of daily living are difficult to meet. Patients whose ability to speak is interrupted (aphasia) but who are unaffected by apraxia are able to live a relatively normal life; those with significant apraxia are almost invariably dependent.
Apraxia comes in several different forms:

Limb-kinetic apraxia is the inability to make precise or exact movements with a finger, an arm or a leg. An example is the inability to use a screwdriver notwithstanding that the person affected understands what is to be done and has done it in the past.

Ideomotor apraxia is the inability to carry out a command from the brain to mimic limb or head movements performed or suggested by others.

Conceptual apraxia is much like ideomotor ataxia but infers a more profound malfunctioning in which the function of tools is no longer understood.

Ideational apraxia is the inability to create a plan for a specific movement.

Buccofacial apraxia, (sometimes called facial-oral apraxia) is the inability to coordinate and carry out facial and lip movements such as whistling, winking, coughing etc on command. This form includes verbal or speech developmental apraxia, perhaps the most common form of the disorder.

Constructional apraxia affects the person's ability to draw or copy simple diagrams or to construct simple figures.

Oculomotor apraxia is a condition in which patients find it difficult to move their eyes.

Apraxia is believed to be caused by a lesion in the neural pathways of the brain that contain the learned patterns of movement. It is often a symptom of neurological, metabolic, or other disorders that can involve the brain.

Symptoms

The major symptom of Apraxia is a person's inability to perform movement in the absence of any physical paralysis. Commands to move are understood, but cannot be executed. When movement is initiated, it is usually very clumsy, uncontrolled and inappropriate. In some cases, movement may occur unintentionally. Apraxia is sometimes accompanied by a person's loss of ability to comprehend or use words (Aphasia).

Specific types of Apraxia are characterized by an inability to perform particular movements on command. For example, in Buccofacial Apraxia, an affected individual is unable to cough, whistle, lick one's lips, or wink when asked. In Constructional Apraxia, an individual is unable to reproduce simple patterns or copy simple drawings.

Causes

Apraxia is caused by a defect in the brain pathways that contain memory of learned patterns of movement. The lesion may be the result of certain metabolic, neurological or other disorders that involve the brain, particularly the frontal lobe (inferior parietal lobule) of the left hemisphere of the brain. In this region, complex, 3-dimensional representations of previously learned patterns and movements are stored. Patients with apraxia cannot retrieve these models of stored skilled movements.

Oculomotor apraxia is a dominant genetic trait. The gene for this condition has been mapped to chromosome 2p13. Each chromosome has a short arm designated "p" and a long arm designated "q". Chromosomes are further sub-divided into many bands that are numbered. For example, "chromosome 2p13" refers to band 13 on the short arm of chromosome 2. The numbered bands specify the location of the thousands of genes that are present on each chromosome.

Genetic diseases are determined by two genes, one received from the father and one from the mother.

Dominant genetic disorders occur when only a single copy of an abnormal gene is necessary for the appearance of the disease. The abnormal gene can be inherited from either parent, or can be the result of a new mutation (gene change) in the affected individual. The risk of passing the abnormal gene from affected parent to offspring is 50% for each pregnancy regardless of the sex of the resulting child.

Tissue or cellular damage (lesions) to other specific parts of the brain, whether as a result of stroke or wounds, tumors, or dementias, may also cause apraxia. These other locations include the so-called supplementary motor area (premotor cortex) or corpus callosum.

If apraxia is the result of a stroke it usually abates within weeks. Some cases of apraxia are congenital. When a child is born with apraxia it is usually the result of malformations of the central nervous system. At the other extreme, individuals with deteriorating intellectual functioning (degenerative dementia) may also develop apraxia.

Individuals with a condition of deteriorating intellectual functioning (degenerative dementia) may also develop Apraxia.

Affected Populations

There is little data available on the incidence of apraxia. Since apraxia may accompany dementia or stroke, it is more frequently diagnosed among older persons.

Related Disorders

The following disorder may be associated with Apraxia as a secondary characteristic. It is not necessary for a differential diagnosis:

Aphasia is a disturbance in the ability to comprehend or use language. It usually occurs as a result of injury to the language centers of the brain (cerebral cortex). Affected individuals may select the wrong words in conversing and may have problems interpreting verbal messages. Children born with Aphasia may not talk at all. A speech therapist may assess the quality and extent of the Aphasia, and help to educate those people who most commonly interact with the affected individual in methods to help communication.

Standard Therapies

When Apraxia is a symptom of an underlying disorder, that disease or condition must be treated. Physical and occupational therapy may be of benefit to stroke and head injured patients. When Apraxia is a symptom of another neurological disorder, the underlying condition must be treated. In some cases, children with apraxia may learn to compensate for deficits as they grow older with the help of special education and physical therapy programs.

Speech therapy and special education may be particularly helpful in treating patients with developmental apraxia of speech.

Investigational Therapies

Information on current clinical trials is posted on the Internet at www.clinicaltrials.gov. All studies receiving U.S. government funding, and some supported by private industry, are posted on this government web site.

For information about clinical trials being conducted at the NIH Clinical Center in Bethesda, MD, contact the NIH Patient Recruitment Office:

Tollfree: (800) 411-1222
TTY: (866) 411-1010
Email: prpl@cc.nih.gov

For information about clinical trials sponsored by private sources, contact:
www.centerwatch.com

Organizations related to Apraxia

References

TEXTBOOKS
Berkow R, Beers M. Eds. The Merck Manual. 17th ed. Merck Research Laboratories, Whitehorse Station, NJ; 1999:1382.

Berkow R. The Merck Manual - Home Edition. Merck Research Laboratories, Whitehorse Station, NJ; 1997:361,362.

Adams RD, Victor M, Ropper AA. Eds. Principles of Neurology. 6th ed. McGraw-Hill Companies. New York, NY; 1997:56-58.

JOURNAL ARTICLES
Leiguarda RC, Merello M, Nouzeilles MI, et al. Limb-kinetic apraxia in corticobasal degeneration: Clinical kinematic features. Mov Disord. 2003;18:49-59.

Nijland L, Maassen B, Van der Muelen S, et al. Coarticulation patterns of children with developmental apraxia of speech. Clin Linguist Phon. 2002;16:461-83.

Wambaugh JL. A summary of treatments for apraxia of speech and review of replicated approaches. Semin Speech Lang. 2002;23:293-308.

Miller N. The neurological bases of apraxia of speech. Semin Speech Lang. 2002;23:293-308.

Hsu HN, Yang ML, Lai HC. Familial congenital ocular motor apraxia. Chang Gung Med J. 2002;25:411-14.

Ruby P, Sirigu A, Decety J. Distinct areas in parietal cortex involved in long-term and short-term action planning: a PET investigation. Cortex. 2002;38:321-39.

Forget R, Tozlovanu V, Iancu A, et al. Botulinum toxin improves lid opening delays in blepharospasm-associated apraxia of lid opening. Neurology. 2002;58:1843-46.

Butler JA. How comparable are tests of apraxia? Clin Rehabil. 2002;16:389-98.

Almeida QJ, Black SE, Roy EA. Screening for apraxia: a short assessment for stroke patients. Brain Cogn. 2002;48:253-58.

Cooper R. Order and disorder in everyday action: the roles of contention scheduling and supervisory attention. Neurocase. 2002;8:61-79.

Koski L, Jacoboni M, Mazziotta JC. Deconstructing apraxia: understanding disorders of intentional movement after stroke. Curr Opin Neurol. 2002;15:71-77.

Buxbaum LJ. Ideomotor apraxia: a call to action. Neurocase. 2002;7:445-58.

Leiguarda R. Limb apraxia: cortical or subcortical. Neuroimage. 2001;14(1 Pt 2):S137-41.

Marshall JC, Fink GR. Spatial cognition: where we were and where we are. Neuroimage. 2001;14(1 Pt 2):S2-7.

Ballard KJ. Response generalization in apraxia of speech treatments: taking another look. J Commun Disord. 2001;34:3-20.

Frith CD, Blakemore SJ, Wolpert DM. Abnormalities in the awareness and control of action. Philos Trans R Soc Lond B Biol Sci. 2000;355:1771-88.

Ochipa C, Gonzalez Rothi LJ. Limb apraxia. Semin Neurol. 2000;20:471-78.
McCormick M. Dyslexia and developmental verbal dyspraxia. Dyslexia. 2000;6:210-14.

Kanda T, Nogawa S, Muramatsu K, et al. Portal systemic encephalopathy presenting with dressing and constructional apraxia. Intern Med. 2000;39:419-23.

Leiguarda RC, Marsden CD. Limb apraxias: higher-order disorders of sensorimotor integration. Brain. 2000;123:860-79.

Leiguarda R, MerelloM, Balej J. Apraxia in corticobasal degeneration. Adv Neurol. 2000;82:61-67.

INTERNET
National Institute on Deafness and Other Communication Disorders. NIDCD Apraxia of Speech. Last Update: 1/2/2003:5pp.
http://www.nidcd.nih.gov/health/voice/apraxia.asp

Jacobs DH. Apraxia and Related Syndromes. eMedicine. Last Updated; 2/28/2002:9pp.
http://www.emedicine.com/NEURO/topic438.htm

National Institute of Neurological Disorders and Stroke. NINDS Apraxia Information Page. Reviewed: 12/17/2001:2pp.
http://www.ninds.nih.gov/health_and_medical/disorders/apraxia.htm

Ferrendelli J. Clinical Correlation: Upper Motor Neuron Dysfunction. Last Modified: 3/23/2001:2pp.
Http://nba19.med.uth.tmc.edu/academic/neuroscience/lectures/section_3/lecture44_02.htm

Apraxia. 2001:2pp.
www.medfriendly.com/apraxia

Mayo Clinic. Developmental Apraxia of Speech. Last Modified: 11/29/2000:2pp.
http://www.mayo.edu/pediatrics-rst/speech-apraxia.html

McKusick VA, Ed. Online Mendelian Inheritance in Man (OMIM). The Johns Hopkins University. Entry Number; 257550: Last Edit Date; 2/6/2000.

McKusick VA, Ed. Online Mendelian Inheritance in Man (OMIM). The Johns Hopkins University. Entry Number; 603119; Last Edit Date; 10/13/1998.

Ocular Motor Apraxia ~ Home Page. nd:2pp.
http://wwweb.org/oma

Ocular Motor Apraxia ~ Information Leaflet. nd:2pp.
http://wwweb.org/oma/leaflet.html

The information in NORD’s Rare Disease Database is for educational purposes only. It should never be used for diagnostic or treatment purposes. If you have questions regarding a medical condition, always seek the advice of your physician or other qualified health professional. NORD’s reports provide a brief overview of rare diseases. For more specific information, we encourage you to contact your personal physician or the agencies listed as “Resources” on this report.

Report last updated: 2008/04/28 00:00:00 GMT+0

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