Common Variable Immune Deficiency
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NORD is very grateful to Charlotte Cunningham-Rundles, MD, PhD, Departments of Medicine, Pediatrics, The Immunology Institute, Mount Sinai School of Medicine, for assistance in the preparation of this report.
Synonyms of Common Variable Immune Deficiency
- Acquired Hypogammaglobulinemia
- common variable hypogammaglobulinemia
- common variable immunodeficiency
- immunodeficiency, common variable
- late-onset immunoglobulin deficiency
- No subdivisions found.
Common Variable Immune Deficiency (CVID) is a type of primary immunodeficiency, which is defined as an immune system dysfunction typically caused by a mutation in a gene or genes. The World Health Organization (WHO) recognizes more than 150 primary immunodeficiencies ranging from relatively common to quite rare.
CVID is one of the most prevalent of primary immunodeficiencies and manifests a wide variability of symptoms and range of severity. It is considered a diverse group of diseases of unknown cause (etiology) as many different immune system defects have been reported. CVID is characterized by a low level of specific proteins (antibodies, also called immunoglobulins) in the fluid portion of the blood which results in a decreasedability to fight invading microorganisms, toxins, or other foreign substances. These immunoglobulins are produced by specialized white blood cells (B cells) as they mature.
The cause of CVID is unknown in 75-80% of cases, and a genetic cause has been identified in 10-20%. Sporadic cases, with no apparent history of the disorder in their family, may be caused by a complex interaction of environmental and genetic components (multifactorial inheritance), but genes that are involved in the development and function of B cells are believed to be the primary cause.
Organizations related to Common Variable Immune Deficiency
(Please note that some of these organizations may provide information concerning certain conditions potentially associated with this disorder [e.g., immune deficiency, autoimmune disorders affecting certain elements of the blood, etc.].)
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