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Arthritis, Reactive

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Copyright 1986, 1994, 1997, 1999, 2007, 2009, 2010

NORD is very grateful to John D. Carter, MD, Associate Professor of Medicine, Chief of Rheumatology, University of South Florida College of Medicine, for assistance in the preparation of this report.

Synonyms of Arthritis, Reactive
  • Fiessinger-Leroy disease
  • ReiterÂ’s syndrome

Disorder Subdivisions



General Discussion
Reactive arthritis is a general term for a form of joint inflammation (arthritis) that develops as a “reaction” to an infection in another area of the body (i.e., outside of the joints). Joint inflammation is characterized by redness, swelling, pain and warmth in and around the affected joint. In reactive arthritis, the joints of the lower limbs are most often affected. Two other common symptoms of reactive arthritis are inflammation of the urinary tract and inflammation of the membrane (conjunctiva) that lines the eyelids (conjunctivitis). These three characteristic symptoms may occur separately, all at once or not at all. Additional symptoms such as fever, weight loss, lower back pain and heel pain may also occur. Reactive arthritis usually develops following a bout with certain bacterial infections including Chlamydia, Salmonella, Shigella, Yersinia, and Campylobacter.

Reactive arthritis belongs to a group of related disorders known as the spondyloarthropathies. These disorders are linked by the association of similar symptoms and a specific genetic marker called HLA-B27. Symptoms common to these disorders include arthritis, especially of the lower limbs, lower back pain and enthesitis, a condition characterized by inflammation at the spot where skeletal muscle attaches to bone. This group of disorders includes reactive arthritis, ankylosing spondylitis, psoriatic arthritis, undifferentiated spondyloarthritis and spondyloarthritis associated with inflammatory bowel disease.

Reactive arthritis is a poorly defined disorder that has been described in the medical literature under many different names. No precise diagnostic or classification criteria have been developed that are universally agreed upon in the medical community.
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Organizations related to Arthritis, Reactive
  • American Autoimmune Related Diseases Association, Inc.
    22100 Gratiot Avenue
    Eastpointe MI 48021
    Phone #: 586-776-3900
    800 #: 800-598-4668
    e-mail: aarda@aarda.org
    Home page: http://www.aarda.org/
  • Arthritis Foundation
    P.O. Box 7669
    Atlanta GA 30357-0669
    Phone #: 404-965-7627
    800 #: 800-283-7800
    e-mail: arthritisfoundation@arthritis.org
    Home page: http://www.arthritis.org
  • Arthritis Society
    393 University Avenue
    Suite 1700
    Toronto
    Ontario Intl M5G IE6
    Phone #: (41-6) -979-7228
    800 #: (80-0) -321-1433
    e-mail: info@arthritis.ca
    Home page: http://www.arthritis.ca
  • Autoimmune Information Network, Inc
    PO Box 4121
    Brick NJ 08723
    Phone #: 732-664-9259
    800 #: N/A
    e-mail: autoimmunehelp@aol.com
    Home page: http://www.aininc.org
  • Centers for Disease Control and Prevention
    1600 Clifton Road
    Atlanta GA 30333
    Phone #: 404-639-3534
    800 #: 800-232-4636
    e-mail: cdcinfo@cdc.gov
    Home page: http://www.cdc.gov/
  • Genetic and Rare Diseases (GARD) Information Center
    PO Box 8126
    Gaithersburg MD 20898-8126
    Phone #: 301-251-4925
    800 #: 888-205-2311
    e-mail: http://rarediseases.info.nih.gov/GARD/EmailForm.aspx
    Home page: http://rarediseases.info.nih.gov/GARD
  • KickAS.org
    11688 North Sage Brook Road
    Oro Valley AZ 85737-7342
    Phone #: 520-544-3023
    800 #: N/A
    e-mail: kickas@gmail.com
    Home page: http://www.kickas.org
  • MUMS National Parent-to-Parent Network
    150 Custer Court
    Green Bay WI 54301-1243
    Phone #: 920-336-5333
    800 #: 877-336-5333
    e-mail: mums@netnet.net
    Home page: http://www.netnet.net/mums/
  • Madisons Foundation
    PO Box 241956
    Los Angeles CA 90024
    Phone #: 310-264-0826
    800 #: N/A
    e-mail: getinfo@madisonsfoundation.org
    Home page: http://www.madisonsfoundation.org
  • NIH/National Arthritis and Musculoskeletal and Skin Diseases Information Clearinghouse
    1 AMS Circle
    Bethesda MD 20892-3675
    Phone #: 301-495-4484
    800 #: 877-226-4267
    e-mail: NIAMSinfo@mail.nih.gov
    Home page: http://www.niams.nih.gov/Health_Info
  • Ocular Immunology and Uveitis Foundation
    5 Cambridge Center
    8th Floor
    Cambridge MA 02142
    Phone #: 617-621-6377
    800 #: 866-353-6377
    e-mail: fosters@comcast.net
    Home page: http://www.uveitis.org
  • Sexuality Information and Education Council of the U.S.
    90 John St. Suite 704,
    New York NY 10038
    Phone #: 212-819-9770
    800 #: --
    e-mail: siecus@siecus.org
    Home page: http://www.siecus.org
  • Spondylitis Association of America
    P.O. Box 5872
    Sherman Oaks CA 91413
    Phone #: 818-892-1616
    800 #: 800-777-8189
    e-mail: info@spondylitis.org
    Home page: http://www.spondylitis.org

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Last modified Wednesday, November 26, 2008