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Guillain Barre Syndrome

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Copyright 1985, 1987, 1988, 1990, 1992, 1996, 1997, 1998, 2002, 2003, 2004, 2007, 2008

This report has been updated in memory of Nuria Zeralda Bey and reviewed by Professor Richard Hughes of the Cochrane Neuromuscular Disease Group at the UCL Institute of Neurology, London ,UK.

Synonyms of Guillain Barre Syndrome
  • Acute Autoimmune Peripheral Neuropathy
  • Acute Immune-Mediated Polyneuropathy
  • Acute Inflammatory Demyelinating Polyneuropathy
  • Acute Inflammatory Demyelinating Polyradiculoneuropathy
  • Acute Inflammatory Neuropathy
  • Acute Inflammatory Polyneuropathy
  • GBS
  • Landry-Guillain-Barre-Strohl Syndrome
  • Landry's Ascending Paralysis
  • Post-Infective Polyneuritis

Disorder Subdivisions

  • Acute Motor Axonal Neuropathy
  • Acute Motor Neuropathy with Conduction Block
  • Acute Motor-Sensory Axonal Neuropathy
  • Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
  • Miller-Fisher Syndrome
  • Multifocal Motor Neuropathy
  • Multifocal Motor Sensory Demyelinating Neuropathy


General Discussion
Guillain-Barré Syndrome (GBS) is a rare, rapidly progressive disorder that consists of inflammation of the nerves (polyneuritis) and, usually causing muscle weakness, sometimes progressing to complete paralysis. Although the precise cause of GBS is unknown, a viral or respiratory infection precedes the onset of the syndrome in about half of the cases. This has led to the theory that GBS may be an autoimmune disease (caused by the body's own immune system). Damage to the covering of nerve cells (myelin) and nerve axons (the extension of the nerve cell that conducts impulses away from the nerve cell body) results in delayed nerve signal transmission. There is a corresponding weakness in the muscles that are supplied by the damaged nerves.

The following variants of GBS (acute inflammatory neuropathy or acute inflammatory demyelinating polyradiculoneuropathy) are recognized: Miller Fisher syndrome, acute motor-sensory axonal neuropathy, acute motor axonal neuropathy.

Organizations related to Guillain Barre Syndrome
  • American Autoimmune Related Diseases Association, Inc.
    22100 Gratiot Avenue
    Eastpointe MI 48021
    Phone #: 586-776-3900
    800 #: 800-598-4668
    e-mail: aarda@aarda.org
    Home page: http://www.aarda.org/
  • AutoImmunity Community
    None
    None None None
    Phone #: (91-9) -552-9057
    800 #: N/A
    e-mail: bandrews@autoimmunitycommunity.org
    Home page: http://autoimmunitycommunity.org
  • Autoimmune Information Network, Inc
    PO Box 4121
    Brick NJ 08723
    Phone #: 732-664-9259
    800 #: N/A
    e-mail: autoimmunehelp@aol.com
    Home page: http://www.aininc.org
  • Christopher Reeve Paralysis Foundation
    636 Morris Turnpike, Suite 3A
    Short Hills NJ 07078
    Phone #: 973-379-2690
    800 #: 800-225-0292
    e-mail: prc@ChristopherReeve.org
    Home page: http://www.christopherreeve.org
  • European Society for Immunodeficiencies (ESID)
    c/o Dr. Bodo Grimbacher (ESID Board Member)
    Division of Rheumatology and Clinical Immunology
    Department of Medicine, University Hospital Freiburg
    Hugstetter Strasse 55
    Freiburg None D-79106
    Phone #: +31- 73--6992965
    800 #: N/A
    e-mail: info@esid.org
    Home page: http://www.esid.org
  • GBS/CIDP Foundation International
    The Holly Building
    104 1/2 Forrest Avenue
    Narberth PA 19072
    Phone #: 610-667-0131
    800 #: 866-224-3301
    e-mail: info@gbs-cidp.org
    Home page: http://www.gbs-cidp.org
  • Guillain-Barre Syndrome Foundation of Canada, Inc.
    PO Box 42016
    2852 John Street
    Markham, Ontario None L3R 5R0
    Phone #: 905--64-0-0073
    800 #: N/A
    e-mail: keast@sprint.ca
    Home page: http://www.gbs-cidp.org
  • Guillain-Barre Syndrome Support Group
    Lincolnshire County Council Offices
    Eastgate
    Sleaford
    Lincolnshire Intl NG34 7EB
    Phone #: +44- 15-29 304615
    800 #: 080-0 3-74803
    e-mail: admin@gbs.org.uk
    Home page: http://www.gbs.org.uk
  • Jack Miller Center for Peripheral Neuropathy
    University of Chicago
    5841 South Maryland Ave, MC 2030
    Chicago IL 60637
    Phone #: 773-702-5800
    800 #: N/A
    e-mail: N/A
    Home page: http://millercenter.uchicago.edu
  • MUMS (Mothers United for Moral Support, Inc) National Parent-to-Parent Network
    150 Custer Court
    Green Bay WI 54301-1243
    Phone #: 920-336-5333
    800 #: 877-336-5333
    e-mail: mums@netnet.net
    Home page: http://www.netnet.net/mums/
  • Madisons Foundation
    PO Box 241956
    Los Angeles CA 90024
    Phone #: 310-264-0826
    800 #: N/A
    e-mail: getinfo@madisonsfoundation.org
    Home page: http://www.madisonsfoundation.org
  • National Foundation for Ectodermal Dysplasias
    410 East Main Street
    PO Box 114
    Mascoutah IL 62258-0114
    Phone #: 618-566-2020
    800 #: --
    e-mail: info@nfed.org
    Home page: http://www.nfed.org
  • National Institute of Neurological Disorders and Stroke (NINDS)
    P.O. Box 5801
    Bethesda MD 20824
    Phone #: 301-496-5751
    800 #: 800-352-9424
    e-mail: me20t@nih.gov
    Home page: http://www.ninds.nih.gov/

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Last modified Wednesday, November 26, 2008