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"Resources" on this report.
Copyright 1992, 1994, 1994, 1999, 2000, 2007
NORD is grateful to Professor Kate Bushby, Neuromuscular Genetics, Institute of Human Genetics, International Centre for Life, Newcastle upon Tyne, UK, for assistance in the preparation of this report.
Synonyms of Muscular Dystrophies, Limb Girdle
- Erb Muscular Dystrophy
- Leyden-Moebius Muscular Dystrophy
- LGMD
- Pelvofemoral Muscular Dystrophy
- Proximal Muscular Dystrophy
Disorder Subdivisions
General Discussion
The limb-girdle muscular dystrophies (LGMD) is a generic term for a group of rare progressive genetic disorders that are characterized by wasting (atrophy) and weakness of the voluntary muscles of the hip and shoulder areas (limb-girdle area). Muscle weakness and atrophy are progressive and may spread to affect other muscles of the body. Approximately 15 different subtypes have been identified based upon abnormal changes (mutations) of certain genes. The age at onset, severity, and progression of symptoms of these subtypes may vary greatly from case to case, even among individuals in the same family. Some individuals may have a mild, slowly progressive form of the disorders; other may have a rapidly progressive form of the disorder that causes severe disability.
The term limb-girdle muscular dystrophies is a general term that encompasses several disorders. These disorders can now be distinguished by genetic and protein analysis. At least 15 subtypes have been identified. The various forms of LGMD may be inherited as autosomal dominant or recessive traits. Autosomal dominant LGMD is known as LGMD1 and has five subtypes (LGMD1A-1E). Autosomal recessive LGMD is known as LGMD2 and has 11 subtypes (LGMDA-K).
Additional terminology has been used in the past to describe forms of muscular dystrophy that are now classified under LGMD. These terms include scapulohumeral (Erb) muscular dystrophy, pelvifemoral (Leyden-Mobius) muscular dystrophy, and severe childhood autosomal recessive muscular dystrophy (SCARMD).
Organizations related to Muscular Dystrophies, Limb Girdle
- Child Neurology Foundation
2000 West 98th Street
Bloomington MN 55431
Phone #: 952-641-6100
800 #: 800-263-5430
e-mail: jstone@childneurologyfoundation.org
Home page: http://www.childneurologyfoundation.org
- Cure CMD (Congenital Muscular Dystrophy)
P.O. Box 701
Olathe KS 66051
Phone #: 866-400-3626
800 #: N/A
e-mail: info@curecmd.com
Home page: http://www.curecmd.org
- Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg MD 20898-8126
Phone #: 301-251-4925
800 #: 888-205-2311
e-mail: ordr@od.nih.gov
Home page: http://rarediseases.info.nih.gov/Default.aspx
- Jain Foundation Inc.
2310 130th Avenue NE, Suite B101
Bellevue WA 98005
Phone #: 425-882-1492
800 #: N/A
e-mail: plavimittal@jain-foundation.org
Home page: http://www.jain-foundation.org
- Let Them Hear Foundation
1900 University Avenue, Suite 101
East Palo Alto CA 94303
Phone #: 650-462-3143
800 #: 877-735-2929
e-mail: info@letthemhear.org
Home page: http://www.letthemhear.org
- MUMS (Mothers United for Moral Support, Inc) National Parent-to-Parent Network
150 Custer Court
Green Bay WI 54301-1243
Phone #: 920-336-5333
800 #: 877-336-5333
e-mail: mums@netnet.net
Home page: http://www.netnet.net/mums/
- Muscular Dystrophy Association
3300 E. Sunrise Dr
Tucson AZ 85718
Phone #: 520-529-2000
800 #: 800-344-4863
e-mail: mda@mdausa.org
Home page: http://www.mdausa.org
- Muscular Dystrophy Campaign
61 Southwark Street
London None SE1 0HL
Phone #: 020- 78-03 4800
800 #: --
e-mail: info@muscular-dystrophy.org
Home page: http://www.muscular-dystrophy.org
- National Institute of Neurological Disorders and Stroke (NINDS)
P.O. Box 5801
Bethesda MD 20824
Phone #: 301-496-5751
800 #: 800-352-9424
e-mail: me20t@nih.gov
Home page: http://www.ninds.nih.gov/
- New Horizons Un-Limited, Inc.
811 East Wisconsin Ave
Suite 937
Milwaukee WI 53202
Phone #: 414-299-0124
800 #: N/A
e-mail: horizons@new-horizons.org
Home page: http://www.new-horizons.org
- Society for Muscular Dystrophy Information International
P.O. Box 7490
Bridgewater
Nova Scotia None B4V 2X6
Phone #: 902--68-5-3961
800 #: --
e-mail: smdi@auracom.com
Home page: http://users.auracom.com/smdi
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