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Copyright 1990, 2000
Synonyms of Paget's Disease of the Breast
- Mammary Paget's Disease
- Paget's Disease of the Nipple
- Paget's Disease of the Nipple and Areola
Disorder Subdivisions
General Discussion
Paget's disease of the breast is a rare form of breast cancer that almost exclusively occurs in women. However, rare cases have been recorded in which men have been affected. The condition was originally reported in 1874 by Sir James Paget, an English surgeon, who also described an unrelated skeletal condition known as Paget's disease of the bone. It is essential to note that these disorders are distinct disease entities that are medically unrelated.
Paget's disease of the breast is characterized by inflammatory, "eczema-like" changes of the nipple that may extend to involve the areola, which is the circular, darkened (pigmented) region of skin surrounding the nipple. Initial findings often include itching (pruritus), scaling, and crusting of and/or discharge from the nipple. In those with Paget's disease of the breast, distinctive tumor cells (known as Paget cells) are present within the outermost layer of skin (epidermis) of the nipple. In addition, the condition is often associated with an underlying malignancy (i.e., cancer) of the milk ducts (ductal carcinoma). The malignancy may be confined to cells lining the milk ducts (carcinoma in situ) or may have invaded surrounding tissue (infiltrating carcinoma). (The milk ducts [lactiferous ducts] are the channels that carry milk secreted by lobes of the breast to the nipple.) Paget's disease of the breast is thought to represent approximately two to four percent of breast cancers.
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Organizations related to Paget's Disease of the Breast
- American Cancer Society, Inc.
1599 Clifton Road NE
Atlanta GA 30329
Phone #: 404-320-3333
800 #: 800-227-2345
e-mail: N/A
Home page: http://www.cancer.org
- Breast Cancer Network of Strength
135 S. LaSalle St.
Suite 2000
Chicago IL 60607
Phone #: 312-986-8338
800 #: 800-221-2141
e-mail: N/A
Home page: http://www.y-me.org
- Breast Cancer Society of Canada
420 East Street North
Sarnia
Ontario None N7T 6Y5
Phone #: 519--33-6-0746
800 #: 800--56-7-8767
e-mail: bcsc@bcsc.ca
Home page: http://www.bcsc.ca
- Canadian Breast Cancer Network
331 Cooper Street, Suite 300
Ottawa
Ontario Intl K2P 0G5
Phone #: 613--23-0-3044
800 #: 1-8-00--685-8820
e-mail: cbcn@cbcn.ca
Home page: http://www.cbcn.ca
- Cancer Support Community
919 18th Street N.W.
Suite 54
Washington DC 20006
Phone #: 202-659-9709
800 #: 888-793-9355
e-mail: N/A
Home page: www.cancersupportcommunity.org
- Friends of Cancer Research
2231 Crystal Drive
Suite 200
Arlington VA 22202
Phone #: 703-302-1503
800 #: N/A
e-mail: info@focr.org
Home page: http://www.focr.org
- Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg MD 20898-8126
Phone #: 301-251-4925
800 #: 888-205-2311
e-mail: http://rarediseases.info.nih.gov/GARD/EmailForm.aspx
Home page: http://rarediseases.info.nih.gov/GARD
- Lance Armstrong Foundation
2201 E. Sixth Street
Austin TX 78702
Phone #: 512-236-8820
800 #: 877-236-8820
e-mail: media@livestrong.org
Home page: http://www.livestrong.org
- National Alliance of Breast Cancer Organizations
9 East 37th Street
10th Floor
New York NY 10016
Phone #: 212-889-0606
800 #: 888-806-2226
e-mail: nabcoinfo@aol.com
Home page: http://www.nabco.org
- National Breast Cancer Coalition
1101 17th Street,
Suite 1300
Washington DC 20036
Phone #: 202-296-7477
800 #: 800-622-2838
e-mail: pgoddard@natlbcc.org
Home page: http://www.natlbcc.org
- National Cancer Institute
6116 Executive Blvd, MSC 8322, Room 3036A
Bethesda MD 20892-8322
Phone #: 301-435-3848
800 #: 800-422-6237
e-mail: cancergovstaff@mail.nih.gov
Home page: http://www.cancer.gov
- National Cancer Institute Physician Data Query (PDQ) Cancer Information Service
9000 Rockville Pike
Bethesda MD 20892
Phone #: --
800 #: 800-422-6237
e-mail: N/A
Home page: http://www.cancernet.nci.nih.gov/pdq.html
- National Women's Health Network
514 10th Street NW
Suite 400
Washington D.C. 20004
Phone #: 202-628-7814
800 #: --
e-mail: nwhn@nwhn.org
Home page: http://www.womenshealthnetwork.org
- OncoLink: The University of Pennsylvania Cancer Center Resource
3400 Spruce Street
2 Donner
Philadelphia PA 19104-4283
Phone #: 215-349-8895
800 #: --
e-mail: hampshire@uphs.upenn.edu
Home page: http://www.oncolink.upenn.edu
- Rare Cancer Alliance
1649 North Pacana Way
Green Valley AZ 85614
Phone #: 520-625-5495
800 #: --
e-mail: sharon.lane@rare-cancer.org
Home page: http://www.rare-cancer.org
- Rose Kushner 's Breast Cancer Advisory Center
Post Office Box 757
Malaga Cove CA 90274
Phone #: --
800 #: --
e-mail: lkkushner@yahoo.com
Home page: http://www.rkbcac.org
- SHARE - Self-Help For Women With Breast or Ovarian Cancer
1501 Broadway
Suite 704A
New York NY 10036
Phone #: 212-719-0364
800 #: --
e-mail: N/A
Home page: http://www.sharecancersupport.org
- Skin Cancer Foundation
149 Madison Avenue
Suite 901
New York NY 10016
Phone #: 212-725-5176
800 #: 800-754-6490
e-mail: info@skincancer.org
Home page: http://www.skincancer.org
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