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Copyright 1995, 1996, 1997, 1998, 2001
Synonyms of Triplo X Syndrome
- 47,XXX Chromosome Constitution
- 47,XXX Karyotype
- 47,XXX Syndrome
- Triple X Syndrome
- Trisomy X
Disorder Subdivisions
General Discussion
Triplo X Syndrome is a chromosomal abnormality that affects females. Females normally have two X chromosomes; however, those with Triplo X Syndrome carry three X chromosomes (trisomy X) in the nuclei of body cells. No specific pattern of symptoms and malformations (phenotype) has been found to be associated with this abnormal chromosomal make-up (i.e., 47,XXX karyotype). Many affected females appear to have no or very few associated symptoms, while others may have various abnormalities.
However, investigators indicate that Triplo X Syndrome is a relatively common cause of learning difficulties, particularly language-based disabilities (e.g., dyslexia), in females. Evidence suggests that affected females typically have normal intelligence with IQs that tend to be lower than that of their brothers and sisters (siblings). Mental retardation rarely occurs. Infants and children with Triplo X Syndrome may tend to have delayed acquisition of certain motor skills and delayed language and speech development.
Affected females often are of tall stature. According to researchers, although sexual development and fertility are usually normal, some may have delayed puberty and/or fertility problems. In addition, in some cases, certain physical abnormalities have been reported, such as a relatively small head, vertical skin folds that may cover the eyes' inner corners (epicanthal folds), and/or other findings. Triplo X Syndrome results from errors during the division of reproductive cells in one of the parents.
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Organizations related to Triplo X Syndrome
- Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg MD 20898-8126
Phone #: 301-251-4925
800 #: 888-205-2311
e-mail: http://rarediseases.info.nih.gov/GARD/EmailForm.aspx
Home page: http://rarediseases.info.nih.gov/GARD
- International Dyslexia Association
40 York Rd., 4th Floor
Baltimore MD 21204
Phone #: 410-296-0232
800 #: 800-222-3123
e-mail: info@interdys.org
Home page: http://www.interdys.org
- Klinefelter Syndrome & Associates (KS&A)
P.O. Box 461047
Aurora CO 80046-1047
Phone #: 303-400-9040
800 #: 888-999-9428
e-mail: info@genetic.org
Home page: http://www.genetic.org
- Learning Disabilities Association of America
4156 Library Road
Pittsburgh PA 15234-1349
Phone #: 412-341-1515
800 #: 888-300-6710
e-mail: info@LDAAmerica.org
Home page: http://www.ldaamerica.org
- MUMS National Parent-to-Parent Network
150 Custer Court
Green Bay WI 54301-1243
Phone #: 920-336-5333
800 #: 877-336-5333
e-mail: mums@netnet.net
Home page: http://www.netnet.net/mums/
- Madisons Foundation
PO Box 241956
Los Angeles CA 90024
Phone #: 310-264-0826
800 #: N/A
e-mail: getinfo@madisonsfoundation.org
Home page: http://www.madisonsfoundation.org
- March of Dimes Birth Defects Foundation
1275 Mamaroneck Avenue
White Plains NY 10605
Phone #: 914-997-4488
800 #: 888-663-4637
e-mail: Askus@marchofdimes.com
Home page: http://www.marchofdimes.com
- National Center for Learning Disabilities
381 Park Avenue South
#1401
New York NY 10016
Phone #: 212-545-7510
800 #: 888-575-7373
e-mail: help@ncld.org
Home page: http://www.ld.org
- National Dissemination Center for Children with Disabilities
P.O. Box 1492
Washington D.C. 20013
Phone #: 202-884-8200
800 #: 800-695-0285
e-mail: nichcy@aed.org
Home page: http://www.nichcy.org
- UNIQUE - Rare Chromosome Disorder Support Group
P.O. Box 2189
Caterham
Surrey Intl CR3 5GN
Phone #: 44 -0 1-883 330766
800 #: --
e-mail: info@rarechromo.org
Home page: http://www.rarechromo.org
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