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"Resources" on this report.
Copyright 1994, 1999, 2007
NORD would like to acknowledge Kelly Trout, RN, BSN, Health Consultant, International WAGR Syndrome Association, for her contribution to this report.
Synonyms of WAGR Syndrome
- 11p deletion syndrome
- Chromosome 11p deletion syndrome
- WAGR Complex
- Wilms' Tumor-Aniridia-Genitourinary Anomalies-Mental Retardation Syndrome
- Wilms' Tumor-Aniridia-Gonadoblastoma-Mental Retardation Syndrome
Disorder Subdivisions
- AGR Triad
- Aniridia-Ambiguous Genitalia-Mental Retardation
- Aniridia-Wilms' Tumor Association
- Aniridia-Wilms' Tumor-Gonadoblastoma
- AWTA
General Discussion
WAGR syndrome is a rare genetic syndrome in which there is a predisposition to several conditions, including certain malignancies, distinctive eye abnormalities, and/or mental retardation. "WAGR" is an acronym for the characteristic abnormalities associated with the syndrome. The acronym stands for (W)ilms' Tumor, the most common form of kidney cancer in children; (A)niridia, partial or complete absence of the colored region of the eye(s) (iris or irides); (G) Genitourinary abnormalities, such as undescended testicles or hypospadias in males, or internal genital or urinary anomalies in females; and Mental (R)etardation. A combination of two or more of these conditions is usually present in most individuals with WAGR syndrome. The clinical picture varies, depending upon the combination of associated abnormalities.
WAGR syndrome is caused by defects (mutations) of adjacent genes on a region of chromosome 11 (11p13). In most cases, such genetic changes (e.g., deletions at band 11p13) occur spontaneously during early embryonic development (de novo) for unknown reasons (sporadic). In very rare cases, the mutation may be inherited as the result of a rearrangement of parts of two chromosomes, which causes the loss of some genetic material (translocation) or other heritable genetic abnormality. The presence of more than one type of chromosomal makeup within an individual (mosaic deletion) resulting in WAGR syndrome has also been reported.
Organizations related to WAGR Syndrome
- Ambiguous Genitalia Support Network
P.O. Box 313
Clements CA 95227-0313
Phone #: 209-727-0313
800 #: --
e-mail: esagsn@hotmail.com
Home page: N/A
- American Cancer Society, Inc.
1599 Clifton Road NE
Atlanta GA 30329
Phone #: 404-320-3333
800 #: 800-227-2345
e-mail: N/A
Home page: http://www.cancer.org
- American Childhood Cancer Organization
10400 Connecticut Avenue
Suite 205
Kensington MD 20895
Phone #: 301-962-3520
800 #: 800-366-2223
e-mail: staff@acco.org
Home page: http://www.candlelighters.org
- American Kidney Fund, Inc.
6110 Executive Boulevard
Suite 1010
Rockville MD 20852
Phone #: 301-881-3052
800 #: 800-638-8299
e-mail: mdemelo@kidneyfund.org
Home page: http://www.kidneyfund.org
- Aniridia Network
109 Gavin Way
Colchester None CO4 9FR
Phone #: (+4-4) -01206 842 742
800 #: N/A
e-mail: hannah@aniridia.org
Home page: http://www.aniridia.org
- Cancer Support Community
919 18th Street N.W.
Suite 54
Washington DC 20006
Phone #: 202-659-9709
800 #: 888-793-9355
e-mail: N/A
Home page: www.cancersupportcommunity.org
- Friends of Cancer Research
2231 Crystal Drive
Suite 200
Arlington VA 22202
Phone #: 703-302-1503
800 #: N/A
e-mail: info@focr.org
Home page: http://www.focr.org
- Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg MD 20898-8126
Phone #: 301-251-4925
800 #: 888-205-2311
e-mail: http://rarediseases.info.nih.gov/GARD/EmailForm.aspx
Home page: http://rarediseases.info.nih.gov/GARD
- Glaucoma Research Foundation
251 Post Street, Suite 600
San Francisco CA 94108
Phone #: 415-986-3162
800 #: 800-826-6693
e-mail: info@glaucoma.org
Home page: http://www.glaucoma.org
- International WAGR Syndrome Association
PO Box 392
Allen Park MI 48101
Phone #: N/A
800 #: --
e-mail: reachingout@wagr.org
Home page: http://www.wagr.org/
- MUMS National Parent-to-Parent Network
150 Custer Court
Green Bay WI 54301-1243
Phone #: 920-336-5333
800 #: 877-336-5333
e-mail: mums@netnet.net
Home page: http://www.netnet.net/mums/
- Madisons Foundation
PO Box 241956
Los Angeles CA 90024
Phone #: 310-264-0826
800 #: N/A
e-mail: getinfo@madisonsfoundation.org
Home page: http://www.madisonsfoundation.org
- March of Dimes Birth Defects Foundation
1275 Mamaroneck Avenue
White Plains NY 10605
Phone #: 914-997-4488
800 #: 888-663-4637
e-mail: Askus@marchofdimes.com
Home page: http://www.marchofdimes.com
- NIH/National Eye Institute
Building 31 Rm 6A32
31 Center Dr MSC 2510
Bethesda MD 20892-2510
Phone #: 301-496-5248
800 #: --
e-mail: 2020@nei.nih.gov
Home page: http://www.nei.nih.gov/
- National Eye Research Foundation
910 Skokie Boulevard
Suite 207A
Northbrook IL 60062
Phone #: 847-564-4652
800 #: 800-621-2258
e-mail: nerf1955@aol.com
Home page: http://www.nerf.org
- National Kidney Foundation
30 East 33rd Street
New York NY 10016
Phone #: 212-889-2210
800 #: 800-622-9010
e-mail: info@kidney.org
Home page: http://www.kidney.org
- Rare Cancer Alliance
1649 North Pacana Way
Green Valley AZ 85614
Phone #: 520-625-5495
800 #: --
e-mail: sharon.lane@rare-cancer.org
Home page: http://www.rare-cancer.org
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