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Yellow Nail Syndrome

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Copyright 1990, 1999, 2000, 2008

NORD is very grateful to Fabien Maldonado, MD, Instructor in Medicine, Fellow, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota, for assistance in the preparation of this report.

Synonyms of Yellow Nail Syndrome
  • Lymphedema with Yellow Nails
  • YNS

Disorder Subdivisions



General Discussion
Yellow nail syndrome is an extremely rare disorder characterized by malformations affecting the fingernails and toenails, abnormalities affecting the lungs and the airways (respiratory tract), and swelling or puffiness in different parts of the body because of the accumulation of protein-rich fluid (lymph) in the soft layers of tissue under the skin (lymphedema). Yellow nail syndrome usually affects older adults. The exact cause of yellow nail syndrome is not known. Yellow nail syndrome has been reported to run in families suggesting that genetic factors may play a role in the development of the disorder in these cases.

Organizations related to Yellow Nail Syndrome
  • American Lung Association
    61 Broadway, 6th Floor
    New York NY 10006
    Phone #: 212-315-8700
    800 #: 800-586-4872
    e-mail: N/A
    Home page: http://www.lungusa.org
  • Genetic and Rare Diseases (GARD) Information Center
    PO Box 8126
    Gaithersburg MD 20898-8126
    Phone #: 301-251-4925
    800 #: 888-205-2311
    e-mail: ordr@od.nih.gov
    Home page: http://rarediseases.info.nih.gov/Default.aspx
  • Lymphatic Research Foundation
    40 Garvies Point Road
    Glen Cove NY 11542
    Phone #: 516-625-9675
    800 #: --
    e-mail: lrf@lymphaticresearch.org
    Home page: http://www.lymphaticresearch.org
  • Lymphovenous Canada
    8 Silver Ave
    Toronto
    Ontario Intl M6R 1X8
    Phone #: 416--53-3-2428
    800 #: N/A
    e-mail: info@lymphovenous-canada.ca
    Home page: http://www.lymphovenous-canada.ca
  • NIH/National Heart, Lung and Blood Institute Information Center
    P.O. Box 30105
    Bethesda MD 20824-0105
    Phone #: 301-592-8573
    800 #: --
    e-mail: nhlbiinfo@rover.nhlbi.nih.gov
    Home page: N/A
  • National Lymphedema Network
    Latham Square Building
    1611 Telegraph Avenue
    Suite 1111
    Oakland CA 94612-2138
    Phone #: 510-208-3200
    800 #: 800-541-3259
    e-mail: nln@lymphnet.org
    Home page: http://www.lymphnet.org

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Last modified Wednesday, November 26, 2008